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612200 Sigma-AldrichTissue Plasminogen Activator, Human

Tissue Plasminogen Activator, Human MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Data Sheet
Required Licenses

Synonyms: tPA

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Overview

Replacement Information

Pricing & Availability

Catalogue Number	Availability	Packaging	Qty/Pack	Price	Quantity
612200-100UG	Retrieving availability... — Limited Availability In Stock Discontinued Limited Quantities Available Availability to be confirmed Login to See Inventory In Stock Limited Availability In Stock Remaining : Will advise Remaining : Will advise Will advise Contact Customer Service Contact Customer Service Contact Customer Service Contact Customer Service	Plastic ampoule	100 μg	Retrieving price... Price could not be retrieved Minimum Quantity is a multiple of Maximum Quantity is Upon Order Completion More Information You Saved () — Request Pricing Login to See Your Pricing	Check Availability —	Add To Favorites Add To Favorites Added To My Favorites
612200-1MG	Retrieving availability... — Limited Availability In Stock Discontinued Limited Quantities Available Availability to be confirmed Login to See Inventory In Stock Limited Availability In Stock Remaining : Will advise Remaining : Will advise Will advise Contact Customer Service Contact Customer Service Contact Customer Service Contact Customer Service	Glass bottle	1 mg	Retrieving price... Price could not be retrieved Minimum Quantity is a multiple of Maximum Quantity is Upon Order Completion More Information You Saved () — Request Pricing Login to See Your Pricing	Check Availability —	Add To Favorites Add To Favorites Added To My Favorites

Description
Overview	Native tissue plasminogen activator from a human melanoma cell line. A serine protease that contains a single chain of 527 amino acids. Binds to fibrin via lysine binding sites at its amino terminus and activates bound plasminogen. Cleaves plasminogen to form active plasmin, the proteolytic enzyme that dissolves clots. Reported to be involved in neurite outgrowth, regeneration, and migration. Plays an important role in excitotoxin-induced neuronal degeneration.
Catalogue Number	612200
Brand Family	Calbiochem®
Synonyms	tPA

References
References	Kim, Y.H., et al. 1999. Science 284, 647. Tsirka, S.E., et al. 1995. Nature 377, 340. Winther, K., et al. 1992. J. Cardiovasc. Pharmacol. 19, S21.

Product Information
Form	Lyophilized
Formulation	Lyophilized from 100 mM PBS, 3.5 mg/ml L-arginine, 0.001% Tween^®-80 Detergent.
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by SDS-PAGE
Source	Prepared from cell line that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Specific Activity	≥300 KU/mg protein

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalogue Number	GTIN
612200-100UG	04055977187762
612200-1MG	04055977187755

Documentation

Required Licenses

Title
CARTA DE USO GENERAL 2016
PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

Tissue Plasminogen Activator, Human SDS

Title
Safety Data Sheet (SDS)

Tissue Plasminogen Activator, Human Certificates of Analysis

Title	Lot Number
612200	Enter Lot Number

References

Reference overview
Kim, Y.H., et al. 1999. Science 284, 647. Tsirka, S.E., et al. 1995. Nature 377, 340. Winther, K., et al. 1992. J. Cardiovasc. Pharmacol. 19, S21.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	17-May-2011 JSW
Synonyms	tPA
Description	Native tissue plasminogen activator from a human melanoma cell line. A serine protease that contains a single chain of 527 amino acid residues. Binds to fibrin via lysine binding sites at its amino terminus and activates bound plasminogen. Cleaves plasminogen to form active plasmin, the proteolytic enzyme that dissolves clots. Reported to be involved in neurite outgrowth, regeneration, and migration. Plays an important role in excitotoxin-induced neuronal degeneration. Dihydropyridine Ca²⁺ antagonist may increase levels of tPA.
Form	Lyophilized
Formulation	Lyophilized from 100 mM PBS, 3.5 mg/ml L-arginine, 0.001% Tween^®-80 Detergent.
Source	Prepared from cell line that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Purity	≥95% by SDS-PAGE
Specific activity	≥300 KU/mg protein
Solubility	Reconstitute with diH₂O to a final concentration of 1 mg/ml (e.g., 100 µg should be reconstituted in 100 µl).
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Kim, Y.H., et al. 1999. Science 284, 647. Tsirka, S.E., et al. 1995. Nature 377, 340. Winther, K., et al. 1992. J. Cardiovasc. Pharmacol. 19, S21.

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