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108219 Tris(hydroxymethyl)aminomethane hydrochloride

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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Trometamol, Aminomethylidine trimethanol, 2-Amino-2-hydroxymethyl-1.3-propanediol, TRIS-buffer

CAS #: 1185-53-1 EC Number: 214-684-5 Molar Mass: 157.60 g/mol Chemical Formula: C₄H₁₁NO₃*ClH Hill Formula: C₄H₁₁NO₃˙ ClH
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108219
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Key Spec Table

CAS #EC NumberHill FormulaChemical FormulaMolar Mass
1185-53-1214-684-5C₄H₁₁NO₃˙ ClHC₄H₁₁NO₃*ClH157.60 g/mol

Pricing & Availability

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1082191000
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      1082195000
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          1082199010
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              1082199012
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                  1082199050
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                      Description
                      Catalogue Number108219
                      SynonymsTrometamol, Aminomethylidine trimethanol, 2-Amino-2-hydroxymethyl-1.3-propanediol, TRIS-buffer
                      DescriptionTris(hydroxymethyl)aminomethane hydrochloride
                      References
                      Product Information
                      CAS number1185-53-1
                      EC number214-684-5
                      Hill FormulaC₄H₁₁NO₃˙ ClH
                      Chemical formulaC₄H₁₁NO₃*ClH
                      Molar Mass157.60 g/mol
                      HS Code2922 19 99
                      Structure formula ImageStructure formula Image
                      Quality LevelMQ500
                      Applications
                      Biological Information
                      Physicochemical Information
                      Density1.28 g/cm3 (20.2 °C)
                      Melting Point150.7 °C
                      pH value4.2 (100 g/l, H₂O, 20 °C)
                      Vapor pressure<0.1 hPa (50 °C)
                      Solubility561 g/l soluble
                      Dimensions
                      Materials Information
                      Toxicological Information
                      Safety Information according to GHS
                      Storage class10 - 13 Other liquids and solids
                      WGKWGK 1 slightly hazardous to water
                      Disposal3
                      Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
                      Safety Information
                      Product Usage Statements
                      Storage and Shipping Information
                      StorageStore at +15°C to +25°C.
                      Packaging Information
                      Transport Information
                      Supplemental Information
                      Specifications
                      Appearancewhite to almost white, crystalline powder
                      Assay (alkalimetric, calculated on dried substance)≥ 99.0 %
                      Identity (IR-spectrum)conforms
                      pH-value (0.5 mol/l, water)3.5 - 5.0
                      Melting point147 - 153 °C
                      UV-Absorption (230 nm; 10 %; 1 cm; water)≤ 0.1
                      UV-Absorption (260 nm; 10 %, 1 cm; water)≤ 0.06
                      UV-Absorption (280 nm; 10 %; 1 cm; water)≤ 0.06
                      UV-Absorption (300 nm; 10 %; 1 cm; water)≤ 0.02
                      UV-Absorption (400 nm; 10 %; 1 cm; water)≤ 0.01
                      Residual solvents (ICHQ3C) of class 2 (Methanol)≤ 3000 ppm
                      Residual solvents (ICHQ3C) of class 2 (Nitromethane)≤ 50 ppm
                      Residual solvents (ICHQ3C) of class 3 (Ethanol)≤ 5000 ppm
                      Residual solvents (ICHQ3C) of class 3 (Ethylmethylketon)≤ 5000 ppm
                      Other residual solvents (ICH Q3C)excluded by manufacturing process
                      Sulfated ash≤ 0.03
                      Loss on Drying (105°C)≤ 0.5
                      Endotoxins< 2.5
                      Total aerobic microbial count≤ 10²
                      Total yeast and mould count
                      ≤ 10²
                      Salmonella spp.
                      absent in 10 g
                      E.coli
                      absent in 1 g
                      Staphylococcus aureus
                      absent in 1 g
                      Pseudomonas aeruginosa
                      absent in 1 g
                      Candida albicans
                      absent in 1 g
                      Bile tolerante gram negative bacteria
                      absent in 1 g
                      DNases (Exo- and endonucleases)
                      not detected
                      Proteases
                      not detected
                      RNases
                      not detected
                      Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
                      Total yeast and mould count
                      ≤ 10²
                      Salmonella spp.
                      absent in 10 g
                      E.coli
                      absent in 1 g
                      Staphylococcus aureus
                      absent in 1 g
                      Pseudomonas aeruginosa
                      absent in 1 g
                      Candida albicans
                      absent in 1 g
                      Bile tolerante gram negative bacteria
                      absent in 1 g
                      DNases (Exo- and endonucleases)
                      not detected
                      Proteases
                      not detected
                      RNases
                      not detected
                      Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
                      Global Trade Item Number
                      Catalogue Number GTIN
                      1082191000 04022536101811
                      1082195000 04022536532899
                      1082199010 04022536702742
                      1082199012 04027269285586
                      1082199050 04054839392443

                      Documentation

                      Material Qualification Dossier

                      TitleVersion
                      7.0

                      Quality Management Dossier (Open Access)

                      Title

                      Operational Excellence Dossier

                      Title

                      Required Licenses

                      Title
                      CARTA DE USO GENERAL 2016
                      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

                      Tris(hydroxymethyl)aminomethane hydrochloride SDS

                      Title

                      Safety Data Sheet (SDS) 

                      Tris(hydroxymethyl)aminomethane hydrochloride Certificates of Analysis

                      Product Number PackagingSpecificationLot Number
                      1082191000 Plastic bottlePDF Specification Document
                      1082195000 Plastic bottlePDF Specification Document
                      1082199010 Plastic drumPDF Specification Document
                      1082199012 Bucket, plasticPDF Specification Document
                      1082199050 Plastic drumPDF Specification Document

                      Certificates

                      Title