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852070 Fmoc-Thr(PO(OBzl)OH)-OH

Fmoc-Thr(PO(OBzl)OH)-OH Novabiochem®. CAS 175291-56-2, molar mass 511.47 g/mol.

Fmoc-Thr(PO(OBzl)OH)-OH MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 175291-56-2 Molar Mass: 511.47 g/mol Hill Formula: C₂₆H₂₆NO₈P
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Key Spec Table

CAS #Hill FormulaMolar Mass
175291-56-2C₂₆H₂₆NO₈P511.47 g/mol

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          Description
          Catalogue Number852070
          Replaces04-12-1155
          Brand Family Novabiochem®
          Alternate Names
          • N-α-Fmoc-O-benzyl-L-phosphothreonine
          Background InformationAn excellent building block for the preparation of phosphothreonine-containing peptides [1, 2]. This derivative can be introduced using standard activation methods, such as PyBOP® and TBTU. The monoprotected phosphothreonine residue once incorporated is stable to piperidine. Using this reagent, even peptides containing multiple phosphorylation sites can be prepared efficiently by standard Fmoc SPPS methods [1].

          A paper describes the use of this derivative in the preparation of phospholamban [3], a 52 residue peptide containing both phosphoserine and phosphothreonine.

          The product number for this product was previously 04-12-1155.

          To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
          References
          Product Information
          CAS number175291-56-2
          Hill FormulaC₂₆H₂₆NO₈P
          Molar Mass511.47 g/mol
          HS Code2924 29 99
          Structure formula ImageStructure formula Image
          Quality LevelMQ200
          Applications
          ApplicationFmoc-Thr(PO(OBzl)OH)-OH Novabiochem®. CAS 175291-56-2, molar mass 511.47 g/mol.
          Biological Information
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Storage class10 - 13 Other liquids and solids
          WGKWGK 3 highly hazardous to water
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          StorageStore at -15°C to -25°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Color (visual)white to slight yellow to beige
          Appearance of substance (visual)powder
          Identity (IR)passes test
          Optical rotation α 25/D (c=1 in DMF)-6.5 - -3.5 °
          Purity (TLC(CMA1))≥ 98 %
          Assay (HPLC, area%)≥ 98.0 % (a/a)
          Solubility (1 mmole in 2 ml DMF)clearly soluble
          Assay (acidimetric)≥ 90.0 %
          Water (K. F.)≤ 2.0 %
          Ethyl acetate (HS-GC)≤ 0.5 %
          Acetate (IC)≤ 0.1 %
          For TLC-Systems see our General Catalog
          Global Trade Item Number
          Catalogue Number GTIN
          8520700001 04027269088156
          8520700005 04027269088163

          Documentation

          Fmoc-Thr(PO(OBzl)OH)-OH SDS

          Title

          Safety Data Sheet (SDS) 

          Citations

          Title
          • [1] P. White & J. Beythien in 'Innovations & Perspectives in Solid Phase Synthesis and Combinatorial Libraries, 4th International Symposium', Mayflower Scientific Ltd., Birmingham, 1996, pp. 557.
          • [2] T. Vorherr, et al. (1995) Bioorg. Med. Chem. Lett., 5, 2661.
          • [3] H. Schmid, et al., Poster 423 presented at the 15th American Peptide Symposium, Nashville, 1997.