On-Demand Webinar

Advanced Perfusion Processes: Design Criteria and Strategies

Duration: 1 Hour
Speaker: Dr. Jochen B. Sieck, Head of Laboratory Cell Culture Performance R&D, Life Science Division, Merck KGaA, Darmstadt, Germany

Abstract: Rising cost pressures in the biopharma industry and the demand for biopharmaceutical companies to diversify their biologics portfolio require them to manufacture in smaller and more flexible plants. New high-density cell culture processes, such as concentrated perfusion, present suitable solutions to adapt to these new manufacturing conditions and to facilitate a shift toward single-use technologies.

Perfusion processing relies on the constant addition of fresh medium and the removal of spent medium from an operating bioreactor. The next generation of perfusion processes might require an increased medium depth; this is partly because of low perfusion rates of 1-2 reactor volumes per day, which sometimes are even smaller than that.

In this webinar we will discuss:

  • The selection and optimization of scale-down models
  • Suitability of single-use bioreactors
  • Approaches for medium development
  • Balancing nutrients
  • Performance optimization using multi-variate approaches
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