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  • Tandem cyclization of α-cyano α-alkynyl aryl ketones induced by tert-butyl hydroperoxide and tetrabutylammonium iodide.

Tandem cyclization of α-cyano α-alkynyl aryl ketones induced by tert-butyl hydroperoxide and tetrabutylammonium iodide.

Organic letters (2012-11-30)
Ying-Chieh Wong, Chen-Tso Tseng, Tzu-Ting Kao, Yu-Cheng Yeh, Kak-Shan Shia
PMID23190145
ABSTRACT

The radical cascade protocol of the α-cyano α-TMS/aryl-capped alkynyl aryl ketones promoted by tert-butyl hydroperoxide under catalysis with tetrabutylammonium iodide in refluxing benzene has been developed, leading to the construction of a variety of highly functionalized [6,6,5] tricyclic frameworks in an efficient manner.

MATERIALS
Product Number
Brand
Product Description
79989
Sigma-Aldrich
Tetrabutylammonium cyanide, technical, ≥80%
416665
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216143
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140775
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361399
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193119
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