Sulfanilamide

Name: Sulfanilamide
Brand: SIAL

≥98% (calc. to the dried substance), solid, purum p.a.

Sinónimos:

p-Aminobenzenesulfonamide

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About This Item

Fórmula lineal:

H₂NC₆H₄SO₂NH₂

Número CAS:

63-74-1

Peso molecular:

172.20

NACRES:

NA.21

PubChem Substance ID:

57648871

eCl@ss:

39093202

UNSPSC Code:

12352100

EC Number:

200-563-4

MDL number:

MFCD00007939

Beilstein/REAXYS Number:

511852

Nombre del producto

Sulfanilamide, puriss. p.a., ≥98% (calc. to the dried substance)

InChI key

FDDDEECHVMSUSB-UHFFFAOYSA-N

InChI

1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10)

SMILES string

Nc1ccc(cc1)S(N)(=O)=O

grade

puriss. p.a.

assay

≥98% (calc. to the dried substance)

form

solid

impurities

≤0.002% heavy metals (as Pb)

ign. residue

≤0.1% (as SO₄)

loss

≤0.5% loss on drying, 105 °C

color

white to faint beige

mp

163-166 °C
164-166 °C (lit.)

anion traces

chloride (Cl^-): ≤100 mg/kg
sulfate (SO₄^2-): ≤200 mg/kg

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

DNA synthesis | interferes
enzyme | inhibits

Quality Level

100

Gene Information

human ... CA1(759), CA2(760), CA5A(763), CA5B(11238), CA9(768)
mouse ... Car13(71934), Car5a(12352)

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Categorías relacionadas

Componentes químicos

Application

Study of new azo-azomethine derivatives of sulfanilamide: synthesis, characterization, spectroscopic, antimicrobial, antioxidant and anticancer activity: This study explores new derivatives of sulfanilamide synthesized through diazonium salt reactions and coupling with 2-hydroxy-3-methoxybenzaldehyde, providing insights into their potential antimicrobial, antioxidant, and anticancer activities (HS Al-Atbi, IJ Al-Assadi, et al., 2020).

General description

Chemical structure: sulfonamide

Sulfanilamide (p-Aminobenzenesulfonamide) is a para-amino substituted benzenesulfonamide. Its ortho-mono and diiodo derivatives have been synthesized.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Packaging

33626-100G; 33626-6X100G

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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CCR1 and CC chemokine ligand 5 interactions exacerbate innate immune responses during sepsis.

Traci L Ness et al.

Journal of immunology (Baltimore, Md. : 1950), 173(11), 6938-6948 (2004-11-24)

CCR1 has previously been shown to play important roles in leukocyte trafficking, pathogen clearance, and the type 1/type 2 cytokine balance, although very little is known about its role in the host response during sepsis. In a cecal ligation and

Heat shock protein 70 is a potential virulence factor in murine toxoplasma infection via immunomodulation of host NF-kappa B and nitric oxide.

Caroline A Dobbin et al.

Journal of immunology (Baltimore, Md. : 1950), 169(2), 958-965 (2002-07-05)

We propose that the 70-kDa heat shock protein (HSP70) protects virulent Toxoplasma gondii from the effects of the host by immunomodulation. This hypothesis was tested using quercetin and antisense oligonucleotides targeting the start codon of the virulent T. gondii HSP70

The Iodination of p-Aminobenzenesulfonamide and Some Symmetrical Azobenzenesulfonamides.

Scudi JV.

Journal of the American Chemical Society, 59(8), 1480-1483 (1937)

IFN-gamma regulates donor CD8 T cell expansion, migration, and leads to apoptosis of cells of a solid tumor.

Joseph A Hollenbaugh et al.

Journal of immunology (Baltimore, Md. : 1950), 177(5), 3004-3011 (2006-08-22)

We previously reported that IFN-gamma secreted by donor cytotoxic T cell 1 (Tc1) cells was the most important factor in promoting EG7 (an OVA transfection the EL4 thymoma) rejection in mice. In this study, we show that the ability of

Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II.

Edward E Knaus et al.

Bioorganic & medicinal chemistry letters, 21(19), 5892-5896 (2011-08-20)

A series of compounds incorporating regioisomeric phenylethynylbenzenesulfonamide moieties has been investigated for the inhibition of four human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms, hCA I, II, IX and XII. Inhibition between the low nanomolar to the milliomolar range has been

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