D5942
DAPT
≥98% (HPLC), solid, γ-secretase inhibitor
Sinónimos:
GSI-IX, LY-374973, Éster t-butílico de N-[N-(3,5-difluorofenacetil)-L-alanil]-S-fenilglicina
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About This Item
Nombre del producto
DAPT, ≥98% (HPLC), solid
SMILES string
C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@@H](C(=O)OC(C)(C)C)c2ccccc2
InChI key
DWJXYEABWRJFSP-VBKZILBWSA-N
InChI
1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20+/m0/s1
biological source
synthetic (organic)
assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: ~18 mg/mL
originator
Eli Lilly
storage temp.
2-8°C
Quality Level
Gene Information
human ... APH1A(51107), APH1B(83464), NCSTN(23385), NOTCH1(4851), NOTCH2(4853), NOTCH3(4854), NOTCH4(4855), PSEN1(5663), PSEN2(5664), PSENEN(55851)
mouse ... Aph1a(226548), Aph1b(208117), Ncstn(59287), Notch1(18128), Notch2(18129), Notch3(18131), Notch4(18132), Psen1(19164), Psen2(19165), Psenen(66340)
rat ... Aph1a(365872), Aph1b(300802), Ncstn(289231), Notch1(25496), Notch2(29492), Notch3(56761), Notch4(406162), Psen1(29192), Psen2(81751), Psenen(292788)
Categorías relacionadas
Application
Biochem/physiol Actions
Features and Benefits
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
What is Product D5942, DAPT soluble in?
DAPT is soluble in DMSO at approximately 18 mg/ml.
Are solutions of Product D5942, DAPT stable?
Sigma has not evaluated the solution stability of DAPT. However, in a study of cultured insect cells, DAPT inhibited γ-secretase activity for 12 hours, which is indicative of its stability in solution at a presumed 37 °C temperature. Pitsi, D., and Octave, J.N., Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of γ-secretase activity. J. Biol. Chem., 279(24), 25333-25338 (2004).
Is Product D5942, DAPT, a reversible or irreversible inhibitor of beta secretase?
The literature indicates that in a treatment of PDAPP neuronal cultures with DAPT, removal of DAPT from the protocol restores amyloid precursor protein β production. This implies that DAPT may be a reversible inhibitor. Dovey, H.F., et al. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J. Neurochem., 76(1), 173-181 (2001).
How do I find price and availability?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| D5942-5MG | 04061833587096 |
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