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CC1059 MMP-7, human, recombinant active form

MMP-7, human, recombinant active form MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Affects Function UniProt Number: P09237
CC1059
10 µg  
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Overview

Replacement Information

Key Spec Table

Key ApplicationsEntrez Gene NumberSpeciesUni Prot Number
FUNCNM_002423.3 Human P09237
Description
Catalogue NumberCC1059
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionMMP-7, human, recombinant active form
OverviewMOLECULAR WT:

19,130 calculated from amino acid sequence and 20,000 from SDS-PAGE, followed by staining with CBB R-250.
Alternate Names
  • Matrilysin
References
Product Information
PresentationSolution in 10 mM HEPES (pH 7.4)-5 mM CaCl2-0.15 M NaCl.
Quality LevelMQ100
Applications
Key Applications
  • Affects Function
Biological Information
Concentration0.1 mg/mL
SourceRecombinant E. Coli; prepared from recombinant human promatrilysin
Specific ActivitySPECIFIC ACTIVITY: <br /><br />5,000 U/mg protein <br /><br />One unit of enzyme activity is defined as the quantity required to digest 1 μg of Azocoll/min. at pH 7.5 and 37°C in the presence of 0.5 mM p-aminophenylmercuric acetate.
Entrez Gene Number
Entrez Gene SummaryProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Gene Symbol
  • MMP7
  • MPSL1
  • matrin
  • MMP-7
  • PUMP-1
  • Matrin
  • PUMP1
  • EC 3.4.24.23
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P09237 # Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
COFACTOR: Binds 2 calcium ions per subunit. & Binds 2 zinc ions per subunit.
SIZE: 267 amino acids; 29677 Da
DOMAIN: SwissProt: P09237 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
SIMILARITY: Belongs to the peptidase M10A family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -80ºC for up to one year.
Packaging Information
Material Size10 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
CC1059 04053252676147

Documentation

Protocols

Title
MMP Activation Chart

MMP-7, human, recombinant active form SDS

Title

Safety Data Sheet (SDS) 

MMP-7, human, recombinant active form Certificates of Analysis

TitleLot Number
MOUSE ANTI-HUMAN CD49f PHYCOERYTHRIN-CONJUGATED MONOCLONAL ANTIBODY 3087150
RECOMBINANT HUMAN MMP-7 MATRILYSIN - 3156043 3156043
RECOMBINANT HUMAN MMP-7 MATRILYSIN - 3321198 3321198
RECOMBINANT HUMAN MMP-7 MATRILYSIN - 3712516 3712516
RECOMBINANT HUMAN MMP-7 MATRILYSIN - 3767443 3767443
RECOMBINANT HUMAN MMP-7 MATRILYSIN - 3821800 3821800
RECOMBINANT HUMAN MMP-7 MATRILYSIN - 3856696 3856696
RECOMBINANT HUMAN MMP-7 MATRILYSIN - 3873579 3873579
RECOMBINANT HUMAN MMP-7 MATRILYSIN - 3915569 3915569
RECOMBINANT HUMAN MMP-7 MATRILYSIN - 3989541 3989541
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