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112251 α₁-Acid Glycoprotein, Human Plasma

112251
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
112251-1MG Plastic ampoule 1 mg
Description
OverviewNative α1-acid glycoprotein from human plasma. Glycoprotein used for the study of the structure of oligosaccharide units. Consists of 40 - 45% carbohydrate. Present in human plasma at concentrations of 55 - 140 mg/100 ml. Clinically, α1-AG is an acute-phase reactant that, together with haptoglobin, indicates acute inflammation. Selectively suppresses the augmentation of NK cell activity by IFN-α and IFN-γ. The α1-AG:α1-antitrypsin ratio is useful in diagnosis of liver disease. A sialic acid-deficient α1-AG has been observed in serum or urine of patients with Hodgkin’s disease, psoriatic arthritis, diabetes, and chronic myeloid leukemia. Sialic acid-deficient α1-AG has an affinity for vitamin B12.
Catalogue Number112251
Brand Family Calbiochem®
Synonymsα₁-AG, C-AGP, Orosomucoid, α₁M-Seromucoid
References
ReferencesAso, H., et al. 1999. Inflammation 23, 117.
Schmid, K., et al. 1973. Biochemistry 12, 2711.
Product Information
CAS number66455-27-4
FormLyophilized
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by SDS-PAGE
SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for to 3 months at (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

α₁-Acid Glycoprotein, Human Plasma SDS

Title

Safety Data Sheet (SDS) 

α₁-Acid Glycoprotein, Human Plasma Certificates of Analysis

TitleLot Number
112251

References

Reference overview
Aso, H., et al. 1999. Inflammation 23, 117.
Schmid, K., et al. 1973. Biochemistry 12, 2711.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-December-2011 JSW
Synonymsα₁-AG, C-AGP, Orosomucoid, α₁M-Seromucoid
DescriptionNative α1-acid glycoprotein from human plasma. Glycoprotein used for the study of the structure of oligosaccharide units. Consists of 40-45% carbohydrate. Present in human plasma at concentrations of 55-140 mg/100 ml. Clinically, α1-AG is an acute phase reactant that, together with haptoglobin, indicates acute inflammation. Selectively suppresses the augmentation of NK cell activity by IFN-α and IFN-γ. The α1-AG:α1-antitrypsin ratio is useful in diagnosis of liver disease. A sialic acid-deficient α1-AG has been observed in serum or urine of patients with Hodgkin's disease, psoriatic arthritis, diabetes, and chronic myeloid leukemia. Sialic acid-deficient α1-AG has an affinity for vitamin B12.
FormLyophilized
SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
CAS number66455-27-4
Purity≥95% by SDS-PAGE
SolubilityAqueous buffers (1 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for to 3 months at (-20°C).
Toxicity Standard Handling
ReferencesAso, H., et al. 1999. Inflammation 23, 117.
Schmid, K., et al. 1973. Biochemistry 12, 2711.