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191500 1-Azakenpaullone - CAS 676596-65-9 - Calbiochem

191500
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₅H₁₀BrN₃O676596-65-9

Products

Catalogue NumberPackaging Qty/Pack
191500-1MG Plastic ampoule 1 mg
Description
OverviewA Kenpaullone (Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC50 = 18 nM), and displays ~100-200 fold greater selectivity over Cdk1/B and Cdk5/p25 (IC50 = 2 µM and 4.2 µM, respectively). Also available as a 10 mM solution in DMSO (Cat. No. 191501).
Catalogue Number191500
Brand Family Calbiochem®
Synonyms1-AKP
References
ReferencesKunick, C., et al. 2004. Bioorg. Med. Chem. Lett. 14, 413.
Product Information
CAS number676596-65-9
ATP CompetitiveY
FormTan solid
Hill FormulaC₁₅H₁₀BrN₃O
Chemical formulaC₁₅H₁₀BrN₃O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGSK-3β
Primary Target IC<sub>50</sub>18 nM against GSK-3β
Purity≥94% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

1-Azakenpaullone - CAS 676596-65-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

1-Azakenpaullone - CAS 676596-65-9 - Calbiochem Certificates of Analysis

TitleLot Number
191500

References

Reference overview
Kunick, C., et al. 2004. Bioorg. Med. Chem. Lett. 14, 413.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-December-2010 JSW
Synonyms1-AKP
DescriptionA Kenpaullone (Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC50 = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC50 = 2.0 µM and 4.2 µM, respectively).
FormTan solid
Intert gas (Yes/No) Packaged under inert gas
CAS number676596-65-9
Chemical formulaC₁₅H₁₀BrN₃O
Structure formulaStructure formula
Purity≥94% by HPLC
SolubilityDMSO (100 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesKunick, C., et al. 2004. Bioorg. Med. Chem. Lett. 14, 413.