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126850 α₁-PDX, Human, Recombinant, E. coli - Calbiochem

126850
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Products

Catalogue NumberPackaging Qty/Pack
126850-2.5MG Plastic ampoule 2.5 mg
Description
OverviewRecombinant protein derived from the bioengineered human α1-antitrypsin gene fused to a His•Tag® sequence and a FLAG®-tag. Contains a minimal furin consensus sequence, RXXR, that effectively blocks the furin-dependent processing of protein precursors (Ki = 600 pM). Extracellular application of α1-PDX can be used to inhibit the processing of biologically significant proteins including viral envelope glycoproteins, bacterial toxins, receptors, and growth factors. Useful for in vivo and in vitro furin inhibition assays.
Catalogue Number126850
Brand Family Calbiochem®
Synonymsα₁-Antitrypsin Portland
References
ReferencesBassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10326.
Jean, F., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2864.
Jean, F., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 7293.
Product Information
ATP CompetitiveN
FormLyophilized solid
FormulationLyophilized from PBS.
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetFurin-dependent processing of protein precursors
Primary Target K<sub>i</sub>600 pM against furin-dependent processing of protein precursors
Purity≥80% by SDS-PAGE
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Yes
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

α₁-PDX, Human, Recombinant, E. coli - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

α₁-PDX, Human, Recombinant, E. coli - Calbiochem Certificates of Analysis

TitleLot Number
126850

References

Reference overview
Bassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10326.
Jean, F., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2864.
Jean, F., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 7293.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-June-2008 JSW
Synonymsα₁-Antitrypsin Portland
DescriptionRecombinant protein derived from the bioengineered human α1-antitrypsin gene fused to a His·Tag® and a FLAG·Tag. Contains a minimal furin consensus sequence, RXXR, that effectively blocks the furin-dependent processing of protein precursors (Ki = 600 pM). α1-PDX can be used in extracellular applications to block the processing of furin substrates. α1-PDX has been shown to inhibit the processing of biologically significant proteins including viral envelope glycoproteins, bacterial toxins, receptors, and growth factors.
FormLyophilized solid
FormulationLyophilized from PBS.
Concentration Label Please refer to vial label for lot-specific concentration
Purity≥80% by SDS-PAGE
SolubilityH₂O (2.5 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Yes
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10326.
Jean, F., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2864.
Jean, F., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 7293.