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100073 15-PGDH Inhibitor - Calbiochem

100073
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₉H₂₃NO₄S

Products

Catalogue NumberPackaging Qty/Pack
100073-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable, thiazolidinedione derivative that acts as a 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor (IC50 = 25 nM). It is shown to increase PGE2 levels in IL-1β-stimulated A549 cells, dose-dependently, in the range of 0–20 µM, and elicits cochlear blood flow (CBF) increase by 15% and 55% when applied intravenously to 250 g guinea pigs at 10 µg and 20 µg respectively.
Catalogue Number100073
Brand Family Calbiochem®
Synonyms5-(4-(2-Cyclohexylethoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione
References
ReferencesWu, Y., et al. 2011. J. Med. Chem. 54, 5260.
Product Information
FormYellow solid
Hill FormulaC₁₉H₂₃NO₄S
Chemical formulaC₁₉H₂₃NO₄S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

15-PGDH Inhibitor - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

15-PGDH Inhibitor - Calbiochem Certificates of Analysis

TitleLot Number
100073

References

Reference overview
Wu, Y., et al. 2011. J. Med. Chem. 54, 5260.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-June-2012 JSW
Synonyms5-(4-(2-Cyclohexylethoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione
DescriptionA cell-permeable, thiazolidinedione derivative that acts as a 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor (IC50 = 25 nM). It is shown to increase PGE2 levels in IL-1β-stimulated A549 cells, dose-dependently, in the range of 0–20 µM, and elicits cochlear blood flow (CBF) increase by 15% and 55% when applied intravenously to 250 g guinea pigs at 10 µg and 20 µg respectively.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₉H₂₃NO₄S
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (100 mg/ml; clear, pale yellow solution)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesWu, Y., et al. 2011. J. Med. Chem. 54, 5260.