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100069 17-DMAG - CAS 467214-21-7 - Calbiochem

100069
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
467214-21-7C₃₂H₄₈N₄O₈ • HCl

Products

Catalogue NumberPackaging Qty/Pack
100069-500UG Plastic ampoule 500 μg
Description
OverviewA potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen), and displays excellent bioavailability and aqueous solubility.
Catalogue Number100069
Brand Family Calbiochem®
SynonymsNSC 707545, 17-Desmethoxy-17-N,N-dimethylaminoethylamino-geldanamycin, HCl, 17-N,N-Dimethylaminoethylamino-17-demethoxy-geldanamycin, HCl, 17DMAG
References
ReferencesTian, Z.Q., et al. 2004. Bioorg. Med. Chem. 12, 5317.
Jez, J.M., et al. 2003. Chem. Biol. 10, 361.
Egorin, M.J., et al. 2002. Cancer Chemother. Pharmacol. 49, 7.
Product Information
CAS number467214-21-7
ATP CompetitiveN
FormPurple solid
Hill FormulaC₃₂H₄₈N₄O₈ • HCl
Chemical formulaC₃₂H₄₈N₄O₈ • HCl
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Application17-DMAG, CAS 467214-21-7, is a more potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM).
Biological Information
Primary Target17-DMAG
Primary Target IC<sub>50</sub>GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen
Purity≥95% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

17-DMAG - CAS 467214-21-7 - Calbiochem Certificates of Analysis

TitleLot Number
100069

References

Reference overview
Tian, Z.Q., et al. 2004. Bioorg. Med. Chem. 12, 5317.
Jez, J.M., et al. 2003. Chem. Biol. 10, 361.
Egorin, M.J., et al. 2002. Cancer Chemother. Pharmacol. 49, 7.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-March-2011 RFH
SynonymsNSC 707545, 17-Desmethoxy-17-N,N-dimethylaminoethylamino-geldanamycin, HCl, 17-N,N-Dimethylaminoethylamino-17-demethoxy-geldanamycin, HCl, 17DMAG
DescriptionA cell-permeable, water soluble, potent anti-tumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen).
FormPurple solid
Intert gas (Yes/No) Packaged under inert gas
CAS number467214-21-7
Chemical formulaC₃₂H₄₈N₄O₈ • HCl
Structure formulaStructure formula
Purity≥95% by TLC
SolubilityDMSO (5 mg/ml) or H₂O (10 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTian, Z.Q., et al. 2004. Bioorg. Med. Chem. 12, 5317.
Jez, J.M., et al. 2003. Chem. Biol. 10, 361.
Egorin, M.J., et al. 2002. Cancer Chemother. Pharmacol. 49, 7.