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208721 ALLM - CAS 110115-07-6 - Calbiochem

208721
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₉H₃₅N₃O₄S110115-07-6

Products

Catalogue NumberPackaging Qty/Pack
208721-25MG Plastic ampoule 25 mg
Description
OverviewCell permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. A weak inhibitor of proteasome.
Catalogue Number208721
Brand Family Calbiochem®
SynonymsCalpain Inhibitor II
References
ReferencesRavid, T., et al. 2000. J. Biol. Chem. 275, 35840.
Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
Sarin, A., et al. 1994. J. Immunol. 153, 862.
Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
Banik, N.L., et al. 1992. Neurochem. Res. 17, 797.
Koohmaraie, M. 1992. Biochemie 74, 239.
Pinter, M., et al. 1992. Biochemistry 31, 8201.
Shenoy, A.M., and Brahmi, Z. 1991. Cell. Immunol. 138, 24.
Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.
Product Information
CAS number110115-07-6
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₁₉H₃₅N₃O₄S
Chemical formulaC₁₉H₃₅N₃O₄S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcalpain-1
Primary Target K<sub>i</sub>120 nM, 230 nM, 100 nM, and 600 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively
Purity>95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceN-Acetyl-Leu-Leu-Met
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

ALLM - CAS 110115-07-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

ALLM - CAS 110115-07-6 - Calbiochem Certificates of Analysis

TitleLot Number
208721

References

Reference overview
Ravid, T., et al. 2000. J. Biol. Chem. 275, 35840.
Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
Sarin, A., et al. 1994. J. Immunol. 153, 862.
Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
Banik, N.L., et al. 1992. Neurochem. Res. 17, 797.
Koohmaraie, M. 1992. Biochemie 74, 239.
Pinter, M., et al. 1992. Biochemistry 31, 8201.
Shenoy, A.M., and Brahmi, Z. 1991. Cell. Immunol. 138, 24.
Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Proteasomes Technical Bulletin

Citations

Title
  • Masako Shimada, et al. (2005) The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit. Endocrinology 146, 2336-2344.
  • Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision03-October-2007 RFH
    SynonymsCalpain Inhibitor II
    DescriptionA cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Also prevents nitric oxide produced by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.
    FormOff-white solid
    CAS number110115-07-6
    Chemical formulaC₁₉H₃₅N₃O₄S
    Peptide SequenceN-Acetyl-Leu-Leu-Met
    Structure formulaStructure formula
    Purity>95% by HPLC
    SolubilityDMSO (5 mg/ml), Ethanol (5 mg/ml), and Methanol (5 mg/ml)
    Storage +2°C to +8°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Standard Handling
    ReferencesRavid, T., et al. 2000. J. Biol. Chem. 275, 35840.
    Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
    Sarin, A., et al. 1994. J. Immunol. 153, 862.
    Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
    Banik, N.L., et al. 1992. Neurochem. Res. 17, 797.
    Koohmaraie, M. 1992. Biochemie 74, 239.
    Pinter, M., et al. 1992. Biochemistry 31, 8201.
    Shenoy, A.M., and Brahmi, Z. 1991. Cell. Immunol. 138, 24.
    Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.
    Citation
  • Masako Shimada, et al. (2005) The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit. Endocrinology 146, 2336-2344.