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171259 AMPK Activator III, DHPO - Calbiochem

171259
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₃H₉NO₂

Products

Catalogue NumberPackaging Qty/Pack
171259-25MG 25 mg
Description
OverviewA cell-permeable AMPK activator (20 mg/kg/d i.p. for 21d) that has been shown to attenuate fasting blood glucose, improve glucose disposal, and correct dyslipidemia in genetic (leptin deficient, ob/ob) and dietary (high-fat-fed) mouse models of insulin resistance over controls. IP injections for 14 days increases skeletal muscle glucose uptake by > ~30% and ~70% compared to vehicle-treated lean and obese mice, respectively. Treatment with 100 µM of DHPO results in a small but significant AMPK (Thr172) phosphorylation, and a concentration dependent increase in glucose uptake with a 2-fold increase over controls, in cultured myotubes. Furthermore, 20 nM Compound C demonstrates a 58% and 41% inhibition of DHPO-stimulated glucose up-take at concentrations of 50 µM and 100 µM DHPO, respectively.
Catalogue Number171259
Brand Family Calbiochem®
Synonyms1-oxo-2-(2H-pyrrolium-1-yl)-1H-inden-3-olate, AMPK Signaling Activator III
References
ReferencesKandadi, M.R., et al. 2009. Biochem. Pharmacol. 79, 623.
Product Information
FormOrange solid
Hill FormulaC₁₃H₉NO₂
Chemical formulaC₁₃H₉NO₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity>95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

AMPK Activator III, DHPO - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

AMPK Activator III, DHPO - Calbiochem Certificates of Analysis

TitleLot Number
171259

References

Reference overview
Kandadi, M.R., et al. 2009. Biochem. Pharmacol. 79, 623.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-September-2010 RFH
Synonyms1-oxo-2-(2H-pyrrolium-1-yl)-1H-inden-3-olate, AMPK Signaling Activator III
DescriptionA cell-permeable AMPK activator (20 mg/kg/d i.p. for 21d) that has been shown to attenuate fasting blood glucose, improve glucose disposal, and correct dyslipidemia in genetic (leptin deficient, ob/ob) and dietary (high-fat-fed) mouse models of insulin resistance over controls. IP injections for 14 days increases skeletal muscle glucose uptake by > ~30% and ~70% compared to vehicle-treated lean and obese mice, respectively. Treatment with 100 µM of DHPO results in a small but significant AMPK (Thr172) phosphorylation, and a concentration dependent increase in glucose uptake with a 2-fold increase over controls, in cultured myotubes. Furthermore, 20 nM Compound C demonstrates a 58% and 41% inhibition of DHPO-stimulated glucose up-take at concentrations of 50 µM and 100 µM DHPO, respectively.
FormOrange solid
Chemical formulaC₁₃H₉NO₂
Structure formulaStructure formula
Purity>95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Toxicity Standard Handling
ReferencesKandadi, M.R., et al. 2009. Biochem. Pharmacol. 79, 623.