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118490 ATIC Dimerization Inhibitor - Calbiochem

118490
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
118490-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable dipeptide that reversibly blocks the homodimerization of aminoimidazole carboxamide ribonucleotide transformylase/inosine nomophosphate cyclohydrolase (ATIC) and inhibits its activity (Ki = 691 nM, Kd = 240 nM). AITC is a bifunctional enzyme that catalyzes the last two steps of de novo purine biosynthesis. Increases the intracellular levels of AICAR leading to the activation of AMP-activated protein kinase (AMPK). Shown to reduce cell viability in a dose-dependent manner. Exhibits a longer half-life and sustained AMPK activation (~ 24 hours) compared to AICA-riboside (Cat. No. 123040).
Catalogue Number118490
Brand Family Calbiochem®
SynonymsAc-Arg-Ph(4-NO2)-NEt2, ATIC Inhibitor, AICAR Tfase Inhibitor, AICAR transformylase Inhibitor, AICAR Tranformylase/Inosine Monophosphate Cyclohydrolase Dimerization Inhibitor, AMPK Signaling Activator XI
References
ReferencesSpurr, I.B., et al. 2012. ChemBioChem 13, 1628.
Product Information
FormWhite solid
Hill FormulaC₂₁H₃₃N₇O₅
Chemical formulaC₂₁H₃₃N₇O₅
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetATIC
Primary Target K<sub>i</sub>691 nM (Kd
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceAc-Arg-Ph(4-NO2)-NEt2
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

ATIC Dimerization Inhibitor - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

ATIC Dimerization Inhibitor - Calbiochem Certificates of Analysis

TitleLot Number
118490

References

Reference overview
Spurr, I.B., et al. 2012. ChemBioChem 13, 1628.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-August-2013 JSW
SynonymsAc-Arg-Ph(4-NO2)-NEt2, ATIC Inhibitor, AICAR Tfase Inhibitor, AICAR transformylase Inhibitor, AICAR Tranformylase/Inosine Monophosphate Cyclohydrolase Dimerization Inhibitor, AMPK Signaling Activator XI
DescriptionA cell-permeable dipeptide that reversibly blocks the homodimerization of aminoimidazole carboxamide ribonucleotide transformylase/inosine nomophosphate cyclohydrolase (ATIC) and inhibits its activity (Ki = 691 nM, Kd = 240 nM). AITC is a bifunctional enzyme that catalyzes the last two steps of de novo purine biosynthesis. Increases the intracellular levels of AICAR leading to the activation of AMP-activated protein kinase (AMPK). Shown to reduce cell viability in a dose-dependent manner. Exhibits a longer half-life and sustained AMPK activation (~ 24 hours) compared to AICA-riboside (Cat. No. 123040).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₁H₃₃N₇O₅
Peptide SequenceAc-Arg-Ph(4-NO2)-NEt2
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSpurr, I.B., et al. 2012. ChemBioChem 13, 1628.