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118501 ATM/ATR Kinase Inhibitor - CAS 905973-89-9 - Calbiochem

118501
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
905973-89-9C₂₃H₁₈Cl₃FN₄O₃S

Products

Catalogue NumberPackaging Qty/Pack
118501-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable thiourea compound that selectively inhibits the kinase activity of ATM and ATR (IC50 = ~200 nM) without significant effect against other PIKK family members (PI 3-K, mTOR, and DNA-PK) or kinases that are known to phosphorylate p53 (ERK, CK1, Cdk2, JNK, PKC, CAK, Chk1, PKR, and p38). Shown to reverse senescence in human primary BJ and HMEC cells. Unlike LY 294002 (Cat. No. 440202 and 440204), this inhibitor does not interfere with cellular PI 3-K/PDK1/Akt signaling pathway.
Catalogue Number118501
Brand Family Calbiochem®
SynonymsCGK 733
References
ReferencesGoldstein, M., et al. 2008. Toxicol. Appl. Pharmacol. in press.
Crescenzi, E., et al. 2008. Clin. Cancer Res. 14, 1877.
Cruet-Hennequart, S., et al. 2008. DNA Repair 7, 582.
Won, J., et al. 2006. Nat. Chem. Biol. 2, 369. (RETRACTED)
Product Information
CAS number905973-89-9
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₂₃H₁₈Cl₃FN₄O₃S
Chemical formulaC₂₃H₁₈Cl₃FN₄O₃S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetATM/ATR
Primary Target IC<sub>50</sub>~200 nM against ATM and ATR
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

ATM/ATR Kinase Inhibitor - CAS 905973-89-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

ATM/ATR Kinase Inhibitor - CAS 905973-89-9 - Calbiochem Certificates of Analysis

TitleLot Number
118501

References

Reference overview
Goldstein, M., et al. 2008. Toxicol. Appl. Pharmacol. in press.
Crescenzi, E., et al. 2008. Clin. Cancer Res. 14, 1877.
Cruet-Hennequart, S., et al. 2008. DNA Repair 7, 582.
Won, J., et al. 2006. Nat. Chem. Biol. 2, 369. (RETRACTED)
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-June-2008 JSW
SynonymsCGK 733
DescriptionA cell-permeable thiourea compound that selectively inhibits the kinase activity of ATM and ATR (IC50 ~ 200 nM) without significant effect against other PIKK family members (PI3K, mTOR, and DNA-PK) or kinases that are known to phosphorylate p53 (ERK, CK1, Cdk2, JNK, PKC, CAK, Chk1, PKR, and p38). Shown to reverse senescence in human primary BJ and HMEC cells. Unlike LY 294002 (Cat. No. 440202 and 440204), this inhibitor does not interfere with cellular PI3K-PDK1-Akt signaling pathway.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number905973-89-9
Chemical formulaC₂₃H₁₈Cl₃FN₄O₃S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesGoldstein, M., et al. 2008. Toxicol. Appl. Pharmacol. in press.
Crescenzi, E., et al. 2008. Clin. Cancer Res. 14, 1877.
Cruet-Hennequart, S., et al. 2008. DNA Repair 7, 582.
Won, J., et al. 2006. Nat. Chem. Biol. 2, 369. (RETRACTED)