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112252 Acidic Mammalian Chitinase Inhibitor, Bisdionin F - Calbiochem

112252
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₆H₁₈N₈O₄

Products

Catalogue NumberPackaging Qty/Pack
112252-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable, competitive Acidic Mammalian Chitinase (AMCase) Inhibitor (IC50 = 0.92 µM and Ki = 0.42 µM for hAMCase, and IC50= 2.2 µM for mAMCase, in vitro) that demonstrates 20-fold selectivity for hAMCase over hCHIT1. It is shown to decrease chitinase enzymatic activity (5 mg/kg, i.p.) in the lungs of control PBS- and OVA-challenged mice. Furthermore, it attenuates lung chitinase activity, reduces eosinophil influx, and improves ventilatory function, in vivo, in a murine model of allergic inflammation. It also causes neutrophilia in the lungs of OVA-challenged mice.
Catalogue Number112252
Brand Family Calbiochem®
Synonyms3,7-dimethyl-1-(3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)propyl)-1H-purine-2,6(3H,7H)-dione, AMCase Inhibitor
References
ReferencesSutherland, T.E., et al. 2011. Chem. Biol. 18, 569.
Product Information
FormOff-white powder
Hill FormulaC₁₆H₁₈N₈O₄
Chemical formulaC₁₆H₁₈N₈O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Acidic Mammalian Chitinase Inhibitor, Bisdionin F - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Acidic Mammalian Chitinase Inhibitor, Bisdionin F - Calbiochem Certificates of Analysis

TitleLot Number
112252

References

Reference overview
Sutherland, T.E., et al. 2011. Chem. Biol. 18, 569.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-June-2012 JSW
Synonyms3,7-dimethyl-1-(3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)propyl)-1H-purine-2,6(3H,7H)-dione, AMCase Inhibitor
DescriptionA cell-permeable, competitive Acidic Mammalian Chitinase (AMCase) Inhibitor (IC50 = 0.92 µM and Ki = 0.42 µM for hAMCase, and IC50= 2.2 µM for mAMCase, in vitro) that demonstrates 20-fold selectivity for hAMCase over hCHIT1. It is shown to decrease chitinase enzymatic activity (5 mg/kg, i.p.) in the lungs of control PBS- and OVA-challenged mice. Furthermore, it attenuates lung chitinase activity, reduces eosinophil influx, and improves ventilatory function, in vivo, in a murine model of allergic inflammation. It also causes neutrophilia in the lungs of OVA-challenged mice.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₆H₁₈N₈O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml; clear, nearly colorless solution)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSutherland, T.E., et al. 2011. Chem. Biol. 18, 569.