Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

116812 Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt - CAS 93882-12-3 - Calbiochem

116812
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₆H₁₄ClN₅O₆PS · Na93882-12-3

Products

Catalogue NumberPackaging Qty/Pack
116812-10MG Plastic ampoule 10 mg
Description
OverviewCell-permeable cAMP analog that activates both protein kinase A and protein kinase G. Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Also acts as a potent inhibitor of cGMP-specific phosphodiesterase (IC50 = 900 nM). Inhibits cAMP-specific phosphodiesterase at much higher concentrations (IC50 = 25 µM).
Catalogue Number116812
Brand Family Calbiochem®
SynonymsAdenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt
References
Referencesde Rooij, J., et al. 1998. Nature. 396, 474.
Kawasaki, H., et al. 1998. Science. 282, 2275.
Moed, P.J., et al. 1993. Comp. Biochem. Physiol. 105A, 711.
Connolly, B.J., et al. 1992. Biochem. Pharmacol. 44, 2303.
Phillips, M.E., and Taylor, A. 1992. J. Physiol. 456, 591.
Shipston, M.J., and Antoni, F.A. 1992. Endocrinology 130, 2213.
Datta, R., et al. 1991. Blood 78, 83.
Peters, D.J.M., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 9219.
Sandberg, M., et al. 1991. Biochem. J. 279, 521.
Unterman, T.G., et al. 1991. Endocrinology 128, 2693.
Xu, H., et al. 1989. Brain Res. 504, 36.
Product Information
CAS number93882-12-3
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₆H₁₄ClN₅O₆PS · Na
Chemical formulaC₁₆H₁₄ClN₅O₆PS · Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetProtein kinase A and protein kinase G
Primary Target IC<sub>50</sub>900 nM against cGMP-specific phosphodiesterase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt - CAS 93882-12-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt - CAS 93882-12-3 - Calbiochem Certificates of Analysis

TitleLot Number
116812

References

Reference overview
de Rooij, J., et al. 1998. Nature. 396, 474.
Kawasaki, H., et al. 1998. Science. 282, 2275.
Moed, P.J., et al. 1993. Comp. Biochem. Physiol. 105A, 711.
Connolly, B.J., et al. 1992. Biochem. Pharmacol. 44, 2303.
Phillips, M.E., and Taylor, A. 1992. J. Physiol. 456, 591.
Shipston, M.J., and Antoni, F.A. 1992. Endocrinology 130, 2213.
Datta, R., et al. 1991. Blood 78, 83.
Peters, D.J.M., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 9219.
Sandberg, M., et al. 1991. Biochem. J. 279, 521.
Unterman, T.G., et al. 1991. Endocrinology 128, 2693.
Xu, H., et al. 1989. Brain Res. 504, 36.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2008 RFH
SynonymsAdenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt
DescriptionCell-permeable cAMP analog that activates both protein kinase A and protein kinase G. Induces the guanine-nucleotide-exchange factor activity of EGFI, also known as Epac (exchange protein directly activated by cAMP), and EGFII towards Rap1 both in vivo and in vitro. Also acts as a potent inhibitor of cGMP specific phosphodiesterase (IC50 = 900 nM). Also inhibits cAMP-specific phosphodiesterases at much higher concentrations (IC50 = 25 µM).
FormWhite solid
CAS number93882-12-3
Chemical formulaC₁₆H₁₄ClN₅O₆PS · Na
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (10 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C
Toxicity Standard Handling
Referencesde Rooij, J., et al. 1998. Nature. 396, 474.
Kawasaki, H., et al. 1998. Science. 282, 2275.
Moed, P.J., et al. 1993. Comp. Biochem. Physiol. 105A, 711.
Connolly, B.J., et al. 1992. Biochem. Pharmacol. 44, 2303.
Phillips, M.E., and Taylor, A. 1992. J. Physiol. 456, 591.
Shipston, M.J., and Antoni, F.A. 1992. Endocrinology 130, 2213.
Datta, R., et al. 1991. Blood 78, 83.
Peters, D.J.M., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 9219.
Sandberg, M., et al. 1991. Biochem. J. 279, 521.
Unterman, T.G., et al. 1991. Endocrinology 128, 2693.
Xu, H., et al. 1989. Brain Res. 504, 36.