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119137 Adenosine A2A Receptor Agonist I, CGS 21680, Hydrochloride - CAS 124182-57-6 - Calbiochem

119137
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
119137-5MG Glass bottle 5 mg
Description
OverviewA xanthin derivative that acts as a potent agonist of adenosine A2A receptors (Ki = 27 nM). Exhibits reduced affinity for A2B receptors (Ki = 67 nM), but offers greater selectivity over A1R (Ki = 290 nM) and A3R (88.8 µM). Exerts an anti-inflammatory effect during chronic inflammation and ameliorates the tissue damage associated with collagen-induced arthritis. Also shown to reduce CCR7 Protein Expression in THP1 macrophages. Shown to delay the progressive deterioration of motor performance and prevent a reduction in brain weight in murine model of Huntington's disease. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number119137
Brand Family Calbiochem®
SynonymsCGS-21680, CGS21680, 3-(4-(2-((6-amino-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl)amino)ethyl)phenyl)propanoic acid
References
ReferencesWillians, A. J., et al. 2012. Inflammation. 35, 614.
Mazzon, E. et al. 2011. J Rheumatol. 38, 2119,
Martire, A., et al. 2007. Neurosci Lett. 417, 78.
Chou, S. Y., et al, 2005. Journ Neurochem. 93, 310.
Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol.362 382.
Phillis, J. W., et al. 1990.Brain Res. 509, 328.
Product Information
CAS number124182-57-6
FormWhite solid
FormulationSupplied as a hydrochloride salt.
Hill FormulaC₂₃H₂₉N₇O₆ • HCl
Chemical formulaC₂₃H₂₉N₇O₆ • HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥96% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Adenosine A2A Receptor Agonist I, CGS 21680, Hydrochloride - CAS 124182-57-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Adenosine A2A Receptor Agonist I, CGS 21680, Hydrochloride - CAS 124182-57-6 - Calbiochem Certificates of Analysis

TitleLot Number
119137

References

Reference overview
Willians, A. J., et al. 2012. Inflammation. 35, 614.
Mazzon, E. et al. 2011. J Rheumatol. 38, 2119,
Martire, A., et al. 2007. Neurosci Lett. 417, 78.
Chou, S. Y., et al, 2005. Journ Neurochem. 93, 310.
Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol.362 382.
Phillis, J. W., et al. 1990.Brain Res. 509, 328.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-November-2019 JSW
SynonymsCGS-21680, CGS21680, 3-(4-(2-((6-amino-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl)amino)ethyl)phenyl)propanoic acid
DescriptionA xanthin derivative that acts as a potent agonist of adenosine A2A receptors (Ki = 27 nM). Exhibits reduced affinity for A2B receptors (Ki = 67 nM), but offers greater selectivity over A1R (Ki = 290 nM) and A3R (88.8 µM). Exerts an anti-inflammatory effect during chronic inflammation and ameliorates the tissue damage associated with collagen-induced arthritis. Also shown to reduce CCR7 Protein Expression in THP1 macrophages. Shown to delay the progressive deterioration of motor performance and prevent a reduction in brain weight in murine model of Huntington's disease.
FormWhite solid
FormulationSupplied as a hydrochloride salt.
Intert gas (Yes/No) Packaged under inert gas
CAS number124182-57-6
Chemical formulaC₂₃H₂₉N₇O₆ • HCl
Structure formulaStructure formula
Purity≥96% by HPLC
SolubilityDMSO (100 mM)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesWillians, A. J., et al. 2012. Inflammation. 35, 614.
Mazzon, E. et al. 2011. J Rheumatol. 38, 2119,
Martire, A., et al. 2007. Neurosci Lett. 417, 78.
Chou, S. Y., et al, 2005. Journ Neurochem. 93, 310.
Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol.362 382.
Phillis, J. W., et al. 1990.Brain Res. 509, 328.