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116860 Adenosine Deaminase Inhibitor, DCF - CAS 53910-25-1 - Calbiochem

116860
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₁H₁₆N₄O₄53910-25-1

Products

Catalogue NumberPackaging Qty/Pack
116860-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable purine nucleoside compound that acts as a highly potent, tight binding transition state analog inhibitor of adenosine deaminase (ADA; Ki= 2.5 pM against partially purified human erythrocytes, and 0.48 to 9.1 nM against rat liver, rat intestine, rat hepatoma and human B cells). Reported to be an immunomodulator and exert selective toxicity towards lymphocytes.
Catalogue Number116860
Brand Family Calbiochem®
Synonyms2ʹ-Deoxycoformycin, (8R)-3-(2-deoxy-β-D-erythro- pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, Pentostatin, S. antibioticus
References
ReferencesRobak, T. 2007. Cancer Treat. Rev. 33, 710.
Klohs, W.D. and Kraker, A.J., 1992. Pharmacol. Rev. 44, 459.
Agarwal, R.P., et al. 1977. Biochem. Pharmacol. 26, 359.
Product Information
CAS number53910-25-1
FormWhite solid
Hill FormulaC₁₁H₁₆N₄O₄
Chemical formulaC₁₁H₁₆N₄O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 62-63

Possible risk of impaired fertility.
Possible risk of harm to the unborn child.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Harmful & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Adenosine Deaminase Inhibitor, DCF - CAS 53910-25-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Adenosine Deaminase Inhibitor, DCF - CAS 53910-25-1 - Calbiochem Certificates of Analysis

TitleLot Number
116860

References

Reference overview
Robak, T. 2007. Cancer Treat. Rev. 33, 710.
Klohs, W.D. and Kraker, A.J., 1992. Pharmacol. Rev. 44, 459.
Agarwal, R.P., et al. 1977. Biochem. Pharmacol. 26, 359.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-May-2012 JSW
Synonyms2ʹ-Deoxycoformycin, (8R)-3-(2-deoxy-β-D-erythro- pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, Pentostatin, S. antibioticus
DescriptionA cell-permeable purine nucleoside compound that acts as a highly potent, tight binding transition state analog inhibitor of adenosine deaminase (ADA; Ki= 2.5 pM against partially purified human erythrocytes, and 0.48 to 9.1 nM against rat liver, rat intestine, rat hepatoma and human B cells). Reported to be an immunomodulator and exert selective toxicity towards lymphocytes.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number53910-25-1
Chemical formulaC₁₁H₁₆N₄O₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml; clear, colorless solution) or H₂O (50 mg/ml; clear, colorless solution)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
ReferencesRobak, T. 2007. Cancer Treat. Rev. 33, 710.
Klohs, W.D. and Kraker, A.J., 1992. Pharmacol. Rev. 44, 459.
Agarwal, R.P., et al. 1977. Biochem. Pharmacol. 26, 359.