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116890 Adenosine Kinase Inhibitor - CAS 214697-26-4 - Calbiochem

116890
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₂H₁₉BrN₆O214697-26-4

Products

Catalogue NumberPackaging Qty/Pack
116890-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable, non-nucleoside pyridopyrimidine compound that acts as a potent, adenosine-competitive, and reversible adenosine kinase (AK) inhibitor (IC50 = 50.7 nM using intact IMR-32 cells and 1.7 nM in cell-free assays using rat brain cytosolic AK). The inhibitory effect is not species-specific and its pharmacological selectivity is confirmed using a panel of more than 80 other enzymes, ion channels, and receptors, including various adesine receptors. It readily crosses the blood-brain barrier and is shown to be efficacious in in vivo animal models via various administration methods (i.p., p.o., s.c.).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without salt molecules.
Catalogue Number116890
Brand Family Calbiochem®
Synonyms4-Amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, 2HCl, ABT-702
References
ReferencesDe Vry, J., et al. 2004. Eur. J. Pharmacol. 491, 137.
Suzuki, R., et al. 2001. Br. J. Pharmacol. 132, 1615.
Boyle, D.L., et al. 2001. J. Pharmacol. Exp. Ther. 296, 495.
Kowaluk, E.A., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1165.
Jarvis, M.F., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1156.
Product Information
CAS number214697-26-4
ATP CompetitiveN
FormYellow to orange solid
Hill FormulaC₂₂H₁₉BrN₆O
Chemical formulaC₂₂H₁₉BrN₆O
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetAdenosine Kinase
Primary Target IC<sub>50</sub>50.7 nM inhibiting adenosine kinase (AK) using intact IMR-32 cells and 1.7 nM in cell-free assays using rat brain cytosolic AK
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Adenosine Kinase Inhibitor - CAS 214697-26-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Adenosine Kinase Inhibitor - CAS 214697-26-4 - Calbiochem Certificates of Analysis

TitleLot Number
116890

References

Reference overview
De Vry, J., et al. 2004. Eur. J. Pharmacol. 491, 137.
Suzuki, R., et al. 2001. Br. J. Pharmacol. 132, 1615.
Boyle, D.L., et al. 2001. J. Pharmacol. Exp. Ther. 296, 495.
Kowaluk, E.A., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1165.
Jarvis, M.F., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1156.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-December-2018 JSW
Synonyms4-Amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, 2HCl, ABT-702
DescriptionA cell-permeable, non-nucleoside pyridopyrimidine compound that acts as a potent, adenosine-competitive, and reversible adenosine kinase (AK) inhibitor (IC50 = 50.7 nM using intact IMR-32 cells and 1.7 nM in cell-free assays using rat brain cytosolic AK). The inhibitory effect is not species-specific and its pharmacological selectivity is confirmed using a panel of more than 80 other enzymes, ion channels, and receptors, including various adesine receptors. It readily crosses the blood-brain barrier and is shown to be efficacious in in vivo animal models via various administration methods (i.p., p.o., s.c.).
FormYellow to orange solid
CAS number214697-26-4
Chemical formulaC₂₂H₁₉BrN₆O
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (20 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesDe Vry, J., et al. 2004. Eur. J. Pharmacol. 491, 137.
Suzuki, R., et al. 2001. Br. J. Pharmacol. 132, 1615.
Boyle, D.L., et al. 2001. J. Pharmacol. Exp. Ther. 296, 495.
Kowaluk, E.A., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1165.
Jarvis, M.F., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1156.