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116850 Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem

116850
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
299442-43-6C₁₂H₁₁N₃O₂

Products

Catalogue NumberPackaging Qty/Pack
116850-25MG Plastic ampoule 25 mg
116850-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable quinazolinone containing a non-nucleoside compound that acts as a potent, selective inhibitor of adenylyl cyclase (AC) type V isoform (IC50 = 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively) in the presence of Gsα GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Regulates the AC catalytic activity in heart and lung tissues.
Catalogue Number116850
Brand Family Calbiochem®
Synonyms2-Amino-7-(furanyl)-7,8-dihydro-5(6H)-quinazolinone
References
ReferencesOnda, T., et al. 2001. J. Biol. Chem. 276, 47785.
Product Information
CAS number299442-43-6
ATP CompetitiveN
FormPale orange solid
Hill FormulaC₁₂H₁₁N₃O₂
Chemical formulaC₁₂H₁₁N₃O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetAdenylate cyclase (AC) type V isoform
Primary Target IC<sub>50</sub>8.3 µM, 132 µM and 1.7 mM for type V, III and II, of adenylyl cyclase (AC), respectively, in the presence of Gsα GTPγS-Forskolin
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem Certificates of Analysis

TitleLot Number
116850

References

Reference overview
Onda, T., et al. 2001. J. Biol. Chem. 276, 47785.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-April-2011 RFH
Synonyms2-Amino-7-(furanyl)-7,8-dihydro-5(6H)-quinazolinone
DescriptionA cell-permeable, non-nucleoside compound that acts as a potent, and selective inhibitor of adenylyl cyclase (AC) type V (IC50 = 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively) in the presence of G5α GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Reported to regulate AC catalytic activity in heart and lung tissues.
FormPale orange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number299442-43-6
Chemical formulaC₁₂H₁₁N₃O₂
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (200 mg/ml) or Methanol (5 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesOnda, T., et al. 2001. J. Biol. Chem. 276, 47785.