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182705 AhR Antagonist - CAS 301326-22-7 - Calbiochem

182705
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₉H₁₉N₅O301326-22-7

Products

Catalogue NumberPackaging Qty/Pack
182705-10MG Plastic ampoule 10 mg
Description
OverviewA cell-permeable pyrazolo-amide compound that potently blocks the binding of TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) to AhR (aryl hydrocarbon receptor) in a dose-dependent manner. Shown to Inhibit TCDD-induced AhR transcription activity in HepG2 cells in vitro (IC50 = 30 nM) and prevent TCDD-elicited liver toxicity and wasting syndrome in mice in vivo. Unlike the commonly used AhR antagonist flavone, this inhibitor has no effect on estrogen receptor transcription activity, nor does it exhibit TCDD-like agonist activity even at concentrations as high as 10 µM.
Catalogue Number182705
Brand Family Calbiochem®
Synonyms2-Methyl-2H-pyrazole-3-carboxylic acid-(2-methyl-4-o-tolyl-azophenyl)-amide, CH-223191
References
ReferencesKim, S.H., et al. 2006. Mol. Pharmacol. 69, 1871.
Product Information
CAS number301326-22-7
ATP CompetitiveN
FormOrange-brown
Hill FormulaC₁₉H₁₉N₅O
Chemical formulaC₁₉H₁₉N₅O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetAhR (aryl hydrocarbon receptor)
Primary Target IC<sub>50</sub>30 nM in blocking TCDD-induced AhR transcription activity in HepG2 cells in vitro
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

AhR Antagonist - CAS 301326-22-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

AhR Antagonist - CAS 301326-22-7 - Calbiochem Certificates of Analysis

TitleLot Number
182705

References

Reference overview
Kim, S.H., et al. 2006. Mol. Pharmacol. 69, 1871.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
Synonyms2-Methyl-2H-pyrazole-3-carboxylic acid-(2-methyl-4-o-tolyl-azophenyl)-amide, CH-223191
DescriptionA cell-permeable pyrazolo-amide compound that potently blocks the binding of TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) to AhR (aryl hydrocarbon receptor) in a dose-dependent manner. Shown to Inhibit TCDD-induced AhR transcription activity in HepG2 cells in vitro (IC50 = 30 nM) and prevent TCDD-elicited liver toxicity and wasting syndrome in mice in vivo. Unlike the commonly used AhR antagonist flavone, this inhibitor has no effect on estrogen receptor transcription activity, nor does it exhibit TCDD-like agonist activity even at concentrations as high as 10 µM.
FormOrange-brown
Intert gas (Yes/No) Packaged under inert gas
CAS number301326-22-7
Chemical formulaC₁₉H₁₉N₅O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesKim, S.H., et al. 2006. Mol. Pharmacol. 69, 1871.