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124012 Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem

124012
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₃H₁₆N₆O₄35943-35-2

Products

Catalogue NumberPackaging Qty/Pack
124012-10MG Glass bottle 10 mg
124012-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3. It does not inhibit known upstream activators of Akt, i.e. PI3K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥ 60% in cell proliferation at 20 µM) and in vivo (≥ 80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.). Also available in InSolution™ format (Cat. No. 124038).
Catalogue Number124012
Brand Family Calbiochem®
SynonymsNSC 154020, TCN, Akt/PKB Signaling Inhibitor-2, API-2
References
ReferencesKarst, A., et al. 2006. Cancer Res. 66, 9225.
Yang, L., et al. 2004. Cancer Res. 64, 4394.
Product Information
CAS number35943-35-2
ATP CompetitiveN
FormSolid
Hill FormulaC₁₃H₁₆N₆O₄
Chemical formulaC₁₃H₁₆N₆O₄
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationAkt Inhibitor V, Triciribine, CAS 35943-35-2, is a cell-permeable, selective, reversible inhibitor of the cellular phosphorylation/activation of Akt1/2/3.
Biological Information
Primary TargetAkt1, Akt 2, Akt3
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSRY8455000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem Certificates of Analysis

TitleLot Number
124012

References

Reference overview
Karst, A., et al. 2006. Cancer Res. 66, 9225.
Yang, L., et al. 2004. Cancer Res. 64, 4394.

Brochure

Title
Akt
Biologics 31.1
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-January-2012 RFH
SynonymsNSC 154020, TCN, Akt/PKB Signaling Inhibitor-2, API-2
DescriptionA cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.). Also available in InSolution™ format (Cat. No. 124038.
FormSolid
Intert gas (Yes/No) Packaged under inert gas
CAS number35943-35-2
RTECSRY8455000
Chemical formulaC₁₃H₁₆N₆O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml). Further dilute at aqueous buffer in low micromolar concentrations.
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesKarst, A., et al. 2006. Cancer Res. 66, 9225.
Yang, L., et al. 2004. Cancer Res. 64, 4394.