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124013 Akt Inhibitor VI, Akt-in - Calbiochem

124013
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₈₈H₁₂₃N₂₃O₂₃

Products

Catalogue NumberPackaging Qty/Pack
124013-2MG Plastic ampoule 2 mg
Description
OverviewA reversible 15-mer peptide derived from proto-oncogene TCL1 (amino acids 10-24) that acts as a specific inhibitor of Akt. Shown to bind to Akt-PH domain (Kd ~18 µM) and interfere with the Akt-phosphoinositide interaction, thus hindering membrane translocation from the cytosol and downstream biological responses.
Catalogue Number124013
Brand Family Calbiochem®
SynonymsTCL1₁₀₋₂₄, H-AVTDHPDRLWAWEKF-OH
References
ReferencesHiromura, M., et al. 2004. J. Biol. Chem. 279, 53407.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as an acetate salt.
Hill FormulaC₈₈H₁₂₃N₂₃O₂₃
Chemical formulaC₈₈H₁₂₃N₂₃O₂₃
Hygroscopic Hygroscopic
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetAkt
Primary Target IC<sub>50</sub>Kd ~18 µM in binding to Akt-PH domain
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Akt Inhibitor VI, Akt-in - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Akt Inhibitor VI, Akt-in - Calbiochem Certificates of Analysis

TitleLot Number
124013

References

Reference overview
Hiromura, M., et al. 2004. J. Biol. Chem. 279, 53407.

Brochure

Title
Akt
Biologics 31.1
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-November-2009 RFH
SynonymsTCL1₁₀₋₂₄, H-AVTDHPDRLWAWEKF-OH
DescriptionA reversible 15-mer peptide derived from the amino acids 10-24 of the proto-oncogene TCL1 (TCL10-24) and acts as a specific inhibitor of Akt. Shown to bind to the Akt-PH domain (Kd ~18 µM) and interfere with the Akt-phosphoinositide interaction. This peptide, when made cell-permeable (Cat. No. 124014), has been shown to hinder Akt membrane translocation from the cytosol and subsequent downstream biological responses.
FormWhite lyophilized solid
FormulationSupplied as an acetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₈₈H₁₂₃N₂₃O₂₃
Peptide SequenceH-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH
Purity≥95% by HPLC
SolubilityH₂O (1 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesHiromura, M., et al. 2004. J. Biol. Chem. 279, 53407.