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172060 Andrographolide - CAS 5508-58-7 - Calbiochem

172060
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₀H₃₀O₅5508-58-7

Products

Catalogue NumberPackaging Qty/Pack
172060-50MG Plastic ampoule 50 mg
Description
OverviewA bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Acts as an irreversible antagonist of NF-κB and AP-1 (IC50 ≤ 15 µM) activation, and prevents in vitro and in vivo T cell activation. Exerts no effect on IκBα degradation, p50 and p65 nuclear translocation. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in mouse model. Further, reported to activate PI 3K/Akt pathway.
Catalogue Number172060
Brand Family Calbiochem®
SynonymsAndro
References
ReferencesXia, Y.F., et al. 2004. J. Immunol. 173, 4207.
Chen, J.H., et al. 2004. Biochem. Pharmacol. 67, 1337.
Yu, B.C., et al. 2003. Planta Med. 69, 1075.
Product Information
CAS number5508-58-7
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₀H₃₀O₅
Chemical formulaC₂₀H₃₀O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNF-κB and AP-1 activation
Primary Target IC<sub>50</sub>≤ 15 µM against NF-κB and AP-1 activation
Purity≥95% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSLU3490750
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Andrographolide - CAS 5508-58-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Andrographolide - CAS 5508-58-7 - Calbiochem Certificates of Analysis

TitleLot Number
172060

References

Reference overview
Xia, Y.F., et al. 2004. J. Immunol. 173, 4207.
Chen, J.H., et al. 2004. Biochem. Pharmacol. 67, 1337.
Yu, B.C., et al. 2003. Planta Med. 69, 1075.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-April-2008 RFH
SynonymsAndro
DescriptionAn irreversible blocker of NF-κB and AP-1 (IC50 ≤ 15 µM) activation that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Exerts no effect on IκBα degradation of nuclear translocation p50 and p65. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in a mouse model. Reported to supress Cytochrome C release and apoptosis by activating the PI 3-K/Akt pathway.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number5508-58-7
RTECSLU3490750
Chemical formulaC₂₀H₃₀O₅
Structure formulaStructure formula
Purity≥95% by TLC
SolubilityDMSO (15 mg/ml) or Chloroform:Methanol (1:1) (10 mg/ml). Use only fresh DMSO.
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
Merck USA index14, 633
ReferencesXia, Y.F., et al. 2004. J. Immunol. 173, 4207.
Chen, J.H., et al. 2004. Biochem. Pharmacol. 67, 1337.
Yu, B.C., et al. 2003. Planta Med. 69, 1075.