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176880 Anisomycin, Streptomyces griseolus - CAS 22862-76-6 - Calbiochem

176880
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₄H₁₉NO₄22862-76-6

Products

Catalogue NumberPackaging Qty/Pack
176880-10MG Alu drum 10 mg
Description
OverviewStrongly activates stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase in mammalian cells. Synergizes with growth factors to induce c-fos and c-jun by acting as a potent signaling agonist. An inhibitor of protein synthesis at the translation step. Also known to induce apoptosis in the human monoblastoid cell line, U937.
Catalogue Number176880
Brand Family Calbiochem®
Synonyms2-(p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate
References
ReferencesHazzalin, C.A., et al. 1998. Mol. Cell. Biol. 18, 1844.
Kardalinou, E., et al. 1994. Mol. Cell. Biol. 14, 1066.
Kyriakis, J.M., et al. 1994. Nature 369, 156.
Sanchez, I., et al. 1994. Nature 372, 794.
Shinohara, K., and Oka, T. 1994. NeuroReport 5, 2201.
Kochi, S. K., and Collier, R.J. 1993. Exp. Cell Res. 208, 296.
Product Information
CAS number22862-76-6
FormWhite solid
Hill FormulaC₁₄H₁₉NO₄
Chemical formulaC₁₄H₁₉NO₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationAnisomycin, Streptomyces griseolus, CAS 22862-76-6, acts as an inhibitor of protein synthesis at the translation step. Strongly activates JNK/SAPK and p38 MAP kinase in mammalian cells.
Biological Information
Purity≥98% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSBZ9800000
Safety Information
R PhraseR: 23/24/25

Toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution store in the refrigerator (4°C). DMSO stock solutions are stable for up to 6 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Anisomycin, Streptomyces griseolus - CAS 22862-76-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Anisomycin, Streptomyces griseolus - CAS 22862-76-6 - Calbiochem Certificates of Analysis

TitleLot Number
176880

References

Reference overview
Hazzalin, C.A., et al. 1998. Mol. Cell. Biol. 18, 1844.
Kardalinou, E., et al. 1994. Mol. Cell. Biol. 14, 1066.
Kyriakis, J.M., et al. 1994. Nature 369, 156.
Sanchez, I., et al. 1994. Nature 372, 794.
Shinohara, K., and Oka, T. 1994. NeuroReport 5, 2201.
Kochi, S. K., and Collier, R.J. 1993. Exp. Cell Res. 208, 296.

Brochure

Title
Antibiotics Profiler
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-June-2009 RFH
Synonyms2-(p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate
DescriptionActivates p54 and MAP kinases. Involved in the activation of stress-activated protein kinases (SAPKs). Synergizes with growth factors to induce c-fos and c-jun by acting as a potent signaling agonist. An inhibitor of protein synthesis at the translation step. Also known to induce apoptosis in the human monoblastoid cell line, U937.
FormWhite solid
CAS number22862-76-6
RTECSBZ9800000
Chemical formulaC₁₄H₁₉NO₄
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (100 mg/ml) or Methanol (50 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution store in the refrigerator (4°C). DMSO stock solutions are stable for up to 6 months at 4°C.
Toxicity Toxic
Merck USA index14, 670
ReferencesHazzalin, C.A., et al. 1998. Mol. Cell. Biol. 18, 1844.
Kardalinou, E., et al. 1994. Mol. Cell. Biol. 14, 1066.
Kyriakis, J.M., et al. 1994. Nature 369, 156.
Sanchez, I., et al. 1994. Nature 372, 794.
Shinohara, K., and Oka, T. 1994. NeuroReport 5, 2201.
Kochi, S. K., and Collier, R.J. 1993. Exp. Cell Res. 208, 296.