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236002 Anti-COX2, C-Terminal Rabbit pAb

236002
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Species ReactivityHostAntibody Type
B, H, M, R, ShRbPolyclonal Antibody

Products

Catalogue NumberPackaging Qty/Pack
236002-50UG Plastic ampoule 50 μg
Description
OverviewRecognizes COX2. Does not cross-react with COX1.
Catalogue Number236002
Brand Family Calbiochem®
SynonymsAnti-Cyclooxygenase-2, Anti-PGHS-2, Anti-Prostaglandin H Synthase-2
References
ReferencesHla, T., and Neilson, K. 1992. Proc. Natl. Acad. Sci. USA 89, 7384.
Product Information
FormLiquid
FormulationIn PBS, 0.1% BSA, pH 7.4.
Preservative≤0.1% sodium azide
Quality LevelMQ100
Applications
Key Applications Enzyme-Linked Immunosorbent Assay
Immunoblotting (Western Blotting)
Application NotesImmunoblotting (1-10 µg/ml, chemiluminescence)
ELISA (1:10,000-1:100,000)
Application CommentsDoes not cross-react with COX1. Variables associated with assay conditions will dictate the optimal working dilution.
Biological Information
Immunogena synthetic peptide corresponding to a 17-amino acid sequence near the C-terminus of human COX2
ImmunogenHuman
HostRabbit
IsotypeIgG
Species Reactivity
  • Bovine
  • Human
  • Mouse
  • Rat
  • Sheep
Antibody TypePolyclonal Antibody
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage -20°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Anti-COX2, C-Terminal Rabbit pAb SDS

Title

Safety Data Sheet (SDS) 

Anti-COX2, C-Terminal Rabbit pAb Certificates of Analysis

TitleLot Number
236002

References

Reference overview
Hla, T., and Neilson, K. 1992. Proc. Natl. Acad. Sci. USA 89, 7384.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-July-2007 RFH
SynonymsAnti-Cyclooxygenase-2, Anti-PGHS-2, Anti-Prostaglandin H Synthase-2
ApplicationImmunoblotting (1-10 µg/ml, chemiluminescence)
ELISA (1:10,000-1:100,000)
DescriptionImmunoaffinity purified rabbit polyclonal antibody. Recognizes the ~72 kDa COX2 protein.
BackgroundCOX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Nonsteroidal anti-inflammatory drugs) such as aspirin. Prostaglandins (PGs) formed by the enzymatic activity of COX1 are primarily involved in the regulation of homeostatic functions throughout the body, whereas PGs formed by COX2 primarily mediate pain, fever, and inflammation. COX2 is induced by a wide variety of stimuli and was initially identified as an immediate-early growth response gene. In addition, COX2 expression is markedly increased in 85-90% of human colorectal adenocarcinomas, whereas COX1 levels remain unchanged. COX2 may be involved in angiogenesis, as new angiogenic endothelial cells express the inducible COX2 while normal blood vessels express COX1.
HostRabbit
Immunogen speciesHuman
Immunogena synthetic peptide corresponding to a 17-amino acid sequence near the C-terminus of human COX2
IsotypeIgG
Speciesbovine, human, mouse, rat, sheep
FormLiquid
FormulationIn PBS, 0.1% BSA, pH 7.4.
Concentration Label Please refer to vial label for lot-specific concentration
Preservative≤0.1% sodium azide
CommentsDoes not cross-react with COX1. Variables associated with assay conditions will dictate the optimal working dilution.
Storage -20°C
Avoid freeze/thaw
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Standard Handling
ReferencesHla, T., and Neilson, K. 1992. Proc. Natl. Acad. Sci. USA 89, 7384.