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04-262 Anti-Ubiquitinylated proteins Antibody, clone FK1

04-262
100 µL  
Purchase on Sigma-Aldrich

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Overview

Replacement Information

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
AWB, IHCMPurifiedMonoclonal Antibody
Description
Catalogue Number04-262
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-Ubiquitinylated proteins Antibody, clone FK1
OverviewUbiquitin is a polypeptide of 76 amino acid residues, being a very highly conserved and widely distributed protein in all eukaryotic cells. It has been proposed that ubiquitin plays important roles in various biological processes such as the regulation of cell cycle, DNA replication, DNA repair, stress response, apoptosis, signal transduction, and the biogenesis of ribosome, nucleosome, peroxisome and myofibrils. In these processes, ubiquitin functions as both a signal for protein degradation and as a chaperone promoting the formation of organelles.
References
Product Information
FormatPurified
Presentation100 µL of concentration 1mg/mL purified immunoglobulin in PBS containing 0.1% sodium azide. Dilute to working strength with phosphate buffered saline pH 7.2-7.4.
Quality LevelMQ100
Applications
ApplicationAnti-Ubiquitinylated proteins Antibody, clone FK1 is an antibody against Ubiquitinylated proteins for use in WB, IH.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Biological Information
ImmunogenPoly-ubiquitinylated-lysozyme.
CloneFK1
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityRecognizes only poly-ubiquitinylated proteins and not mono-ubiquitinylated proteins or free ubiquitin.
IsotypeIgM
Species Reactivity
  • All
Antibody TypeMonoclonal Antibody
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of shipment for up to 12 months.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications

Documentation

Anti-Ubiquitinylated proteins Antibody, clone FK1 SDS

Title

Safety Data Sheet (SDS) 

Anti-Ubiquitinylated proteins Antibody, clone FK1 Certificates of Analysis

TitleLot Number
Anti-Ubiquitinylated Proteins, clone FK1 3054660
Anti-Ubiquitinylated Proteins, clone FK1 (mouse monoclonal IgM) - 2117976 2117976
Anti-Ubiquitinylated Proteins, clone FK1 (mouse monoclonal IgM) 2984247
Anti-Ubiquitinylated Proteins, clone FK1 (mouse monoclonal IgM) 3116910
Anti-Ubiquitinylated Proteins, clone FK1 (mouse monoclonal IgM) 2906533
Anti-Ubiquitinylated Proteins, clone FK1 (mouse monoclonal IgM) 3122972
Anti-Ubiquitinylated Proteins, clone FK1 (mouse monoclonal IgM) - 2061417 2061417
Anti-Ubiquitinylated Proteins, clone FK1 (mouse monoclonal IgM) - 2262611 2262611
Anti-Ubiquitinylated Proteins, clone FK1 (mouse monoclonal IgM) - 2272674 2272674
Anti-Ubiquitinylated Proteins, clone FK1 (mouse monoclonal IgM) - NG1938992 NG1938992

References

Reference overviewPub Med ID
Proteasome Inhibition Alleviates SNARE-Dependent Neurodegeneration.
Sharma, Manu, et al.
Sci Transl Med, 4: 147ra113 (2012)  2012

Show Abstract
22896677 22896677
z-Leucinyl-leucinyl-norleucinal induces apoptosis of human glioblastoma tumor-initiating cells by proteasome inhibition and mitotic arrest response.
Monticone M, Biollo E, Fabiano A, Fabbi M, Daga A, Romeo F, Maffei M, Melotti A, Giaretti W, Corte G, Castagnola P
Molecular cancer research : MCR  7  1822-34  2009

Show Abstract
19861404 19861404
Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation
Haglund, Kaisa, et al
Nat Cell Biol, 5:461-6 (2003)  2003

12717448 12717448
Transient aggregation of ubiquitinated proteins during dendritic cell maturation.
Lelouard, Hugues, et al.
Nature, 417: 177-82 (2002)  2002

Show Abstract
12000969 12000969
PI31 is a modulator of proteasome formation and antigen processing.
Zaiss, Dietmar M W, et al.
Proc. Natl. Acad. Sci. U.S.A., 99: 14344-9 (2002)  2002

Show Abstract
12374861 12374861

Data Sheet

Title
Anti-Ubiquitinylated Proteins, clone FK1