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178223 Antipain, Dihydrochloride - CAS 37682-72-7 - Calbiochem

178223
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₇H₄₄N₁₀O₆ · 2HCl37682-72-7

Products

Catalogue NumberPackaging Qty/Pack
178223-10MG Plastic ampoule 10 mg
Description
OverviewPeptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca2+-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain and some cysteine proteases (IC50 = 300 µM).
Effective concentration: 1-100 µM.
Catalogue Number178223
Brand Family Calbiochem®
References
ReferencesLyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
Ichikawa, S., et al. 1985. J. Reprod. Fertil. 73, 385
Umezawa, H. 1976. Methods Enzymol. 55, 678.
Suda, H., et al. 1972. J. Antibiot. (Tokyo) 25, 263.
Product Information
CAS number37682-72-7
ATP CompetitiveN
FormWhite powder
Hill FormulaC₂₇H₄₄N₁₀O₆ · 2HCl
Chemical formulaC₂₇H₄₄N₁₀O₆ · 2HCl
Hygroscopic Hygroscopic
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary Targettrypsin-like serine proteases, papain, and some cysteine proteases
Primary Target IC<sub>50</sub>300 µM against trypsin-like serine proteases, papain and some cysteine proteases; Effective concentration: 1-100 µM
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSYV9350800
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Antipain, Dihydrochloride - CAS 37682-72-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Antipain, Dihydrochloride - CAS 37682-72-7 - Calbiochem Certificates of Analysis

TitleLot Number
178223

References

Reference overview
Lyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
Ichikawa, S., et al. 1985. J. Reprod. Fertil. 73, 385
Umezawa, H. 1976. Methods Enzymol. 55, 678.
Suda, H., et al. 1972. J. Antibiot. (Tokyo) 25, 263.

Citations

Title
  • Masako Shimada, et al. (2005) The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit. Endocrinology 146, 2336-2344.
  • Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision25-September-2014 JSW
    DescriptionA reversible protease inhibitor produced by actinomycetes. Inhibits cathepsin A and B as well as papain, and trypsin-like serine proteases. Acts by forming a hemiacetal adduct between the aldehyde group of the inhibitor and the active proteinase. Effective at concentrations range from 1 to 100 µM.
    FormWhite powder
    CAS number37682-72-7
    RTECSYV9350800
    Chemical formulaC₂₇H₄₄N₁₀O₆ · 2HCl
    Purity≥97% by HPLC
    SolubilityH₂O (1 mg/ml) or DMSO (5 mg/ml)
    Storage +2°C to +8°C
    Hygroscopic
    Protect from light
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
    Toxicity Standard Handling
    ReferencesLyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
    Ichikawa, S., et al. 1985. J. Reprod. Fertil. 73, 385
    Umezawa, H. 1976. Methods Enzymol. 55, 678.
    Suda, H., et al. 1972. J. Antibiot. (Tokyo) 25, 263.
    Citation
  • Masako Shimada, et al. (2005) The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit. Endocrinology 146, 2336-2344.