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178385 Apocynin - CAS 498-02-2 - Calbiochem

178385
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₉H₁₀O₃498-02-2

Products

Catalogue NumberPackaging Qty/Pack
178385-1GM Plastic ampoule 1 gm
Description
OverviewA cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase. Shown to block peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through activation of AP-1. Also reported to prevent phagocytosis of myelin by macrophages (10 mM).
Catalogue Number178385
Brand Family Calbiochem®
Synonyms4-Hydroxy-3-methoxyacetophenone, Acetovanillone, NADPH Oxidase Inhibitor V, NOX Inhibitor V
References
ReferencesAbid, M.R., et al. 2000. FEBS Lett. 486, 252.
Muijsers, R.B., et al. 2000. Br. J. Pharmacol. 130, 932.
Lapperre, T.S., et al. 1999. FEBS Lett. 443, 235.
Supinski, G., et al. 1999, J. Appl. Physiol. 87, 776.
van der Goes, A., et al. 1998. J. Neuroimmunol. 92, 67.
Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther. 3, 3.
Product Information
CAS number498-02-2
ATP CompetitiveN
FormWhite to off-white powder
Hill FormulaC₉H₁₀O₃
Chemical formulaC₉H₁₀O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNADPH oxidase
Purity≥98% by GC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSAM8800000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Apocynin - CAS 498-02-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Apocynin - CAS 498-02-2 - Calbiochem Certificates of Analysis

TitleLot Number
178385

References

Reference overview
Abid, M.R., et al. 2000. FEBS Lett. 486, 252.
Muijsers, R.B., et al. 2000. Br. J. Pharmacol. 130, 932.
Lapperre, T.S., et al. 1999. FEBS Lett. 443, 235.
Supinski, G., et al. 1999, J. Appl. Physiol. 87, 776.
van der Goes, A., et al. 1998. J. Neuroimmunol. 92, 67.
Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther. 3, 3.

Brochure

Title
Pathways and Biomarkers of Oxidative Stress
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-February-2018 JSW
Synonyms4-Hydroxy-3-methoxyacetophenone, Acetovanillone, NADPH Oxidase Inhibitor V, NOX Inhibitor V
DescriptionA cell-permeable, anti-inflammatory phenol that acts as a potent and selective inhibitor of NADPH oxidase. Also blocks peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through the activation of AP-1. Shown to prevent phagocytosis of myelin by macrophages (10 mM).
FormWhite to off-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number498-02-2
RTECSAM8800000
Chemical formulaC₉H₁₀O₃
Structure formulaStructure formula
Purity≥98% by GC
SolubilityDMSO (10 mg/ml) or Ethanol (20 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
Merck USA index14, 741
ReferencesAbid, M.R., et al. 2000. FEBS Lett. 486, 252.
Muijsers, R.B., et al. 2000. Br. J. Pharmacol. 130, 932.
Lapperre, T.S., et al. 1999. FEBS Lett. 443, 235.
Supinski, G., et al. 1999, J. Appl. Physiol. 87, 776.
van der Goes, A., et al. 1998. J. Neuroimmunol. 92, 67.
Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther. 3, 3.