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178488 Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem

178488
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₃H₁₆O₄54135-60-3

Products

Catalogue NumberPackaging Qty/Pack
178488-10MG Plastic ampoule 10 mg
Description
OverviewA cell-permeable inhibitor of apoptosis induction (IC50 = 67 µg/ml in FasL-stimulated WC8 cells, 130 µg/ml in etoposide-stimulated U937 cells). Effects attributable to the inhibition of caspase-3 activation but does not directly inhibit caspase-3 even at 1 mg/ml.
Catalogue Number178488
Brand Family Calbiochem®
SynonymsM50054, 2,2ʹ-Methylenebis(1,3-cyclohexanedione)
References
ReferencesTsuda, T., et al. 2001. Eur. J. Pharmacol. 433, 37.
Product Information
CAS number54135-60-3
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₁₃H₁₆O₄
Chemical formulaC₁₃H₁₆O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetapoptosis induction
Primary Target IC<sub>50</sub>67 µg/ml in FasL-stimulated WC8 cells, 130 µg/ml in etoposide-stimulated U937 cells
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem Certificates of Analysis

TitleLot Number
178488

References

Reference overview
Tsuda, T., et al. 2001. Eur. J. Pharmacol. 433, 37.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-July-2009 RFH
SynonymsM50054, 2,2ʹ-Methylenebis(1,3-cyclohexanedione)
DescriptionA cell-permeable, bis(cyclohexane-1,3-diketone) that is shown to inhibit apoptosis induction in FasL-stimulated WC8 cells (IC50 = 67 µg/ml) and etoposide-stimulated U937 cells (IC50 = 130 µg/ml). The anti-apoptotic effects have been shown to be attributable to inhibition of caspase-3 activation (IC50 = 334 nM), however it does not exhibit any direct inhibition of caspase-3 enzymatic activity. Shown to inhibit the elevation of the liver enzymes, alanine aminotransferase and aspartate aminotransferase, in a murine model of anti-Fas-induced hepatitis. Topical application has been shown to reduce chemotherapy-induced alopecia (hair loss) in newborn rats.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number54135-60-3
Chemical formulaC₁₃H₁₆O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml) or Ethanol (20 mg/ml)
Storage +2°C to +8°C
Protect from moisture
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesTsuda, T., et al. 2001. Eur. J. Pharmacol. 433, 37.