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182541 Aromatase Inhibitor II, Letrozole - CAS 112809-51-5 - Calbiochem

182541
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₇H₁₁N₅112809-51-5

Products

Catalogue NumberPackaging Qty/Pack
182541-25MG Glass bottle 25 mg
Description
OverviewAn orally bioavailable non-steroidal triazole compound that acts as a potent and selective inhibitor of aromatase (IC50 = 140, 350 and 450 pM in Dex-treated fibroblasts, MCF-7Ca, and JEG-3 cells, respectively). Competitively, but reversibly binds to the heme iron of aromatase. Does not affect the synthesis of adrenal mineralocorticoid or glucocorticoids. Reported to be highly effective as an anti-estrogenic and anti-proliferative agent in estrogen-rich tumors. Also delays the fusing of the growth plates in adolescents and enhances the effectiveness of growth hormone. Shown to synergistically induce apoptosis and cause tumor regression when combined with IGF-1R inhibitors.
Catalogue Number182541
Brand Family Calbiochem®
Synonyms4,4ʹ-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile, 1-(bis-(4-Cyanophenyl)methyl)-1,2,4-triazole
References
ReferencesHou, X., et al. 2011. Cancer Res. 71, 7597.
Lisztwan, J., et al. 2008. Breast Cancer Res. 10, R56.
Miller, W.R., et al. 2002. Cancer Invest. 20 (Suppl 2), 15.
Long, B.J., et al. 1998. J. Steroid Biochem. Molec. Biol. 67, 293.
Product Information
CAS number112809-51-5
FormWhite powder
Hill FormulaC₁₇H₁₁N₅
Chemical formulaC₁₇H₁₁N₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Aromatase Inhibitor II, Letrozole - CAS 112809-51-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Aromatase Inhibitor II, Letrozole - CAS 112809-51-5 - Calbiochem Certificates of Analysis

TitleLot Number
182541

References

Reference overview
Hou, X., et al. 2011. Cancer Res. 71, 7597.
Lisztwan, J., et al. 2008. Breast Cancer Res. 10, R56.
Miller, W.R., et al. 2002. Cancer Invest. 20 (Suppl 2), 15.
Long, B.J., et al. 1998. J. Steroid Biochem. Molec. Biol. 67, 293.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-June-2012 JSW
Synonyms4,4ʹ-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile, 1-(bis-(4-Cyanophenyl)methyl)-1,2,4-triazole
DescriptionAn orally bioavailable non-steroidal triazole compound that acts as a potent and selective inhibitor of aromatase (IC50 = 140, 350 and 450 pM in Dex-treated fibroblasts, MCF-7Ca, and JEG-3 cells, respectively). Competitively, but reversibly binds to the heme iron of aromatase. Does not affect the synthesis of adrenal mineralocorticoid or glucocorticoids. Reported to be highly effective as an anti-estrogenic and anti-proliferative agent in estrogen-rich tumors. Also delays the fusing of the growth plates in adolescents and enhances the effectiveness of growth hormone. Shown to synergistically induce apoptosis and cause tumor regression when combined with IGF-1R inhibitors.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number112809-51-5
Chemical formulaC₁₇H₁₁N₅
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml; clear, colorless solution) or Ethanol (< 5 mg/ml; partially soluble)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesHou, X., et al. 2011. Cancer Res. 71, 7597.
Lisztwan, J., et al. 2008. Breast Cancer Res. 10, R56.
Miller, W.R., et al. 2002. Cancer Invest. 20 (Suppl 2), 15.
Long, B.J., et al. 1998. J. Steroid Biochem. Molec. Biol. 67, 293.