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196322 Baicalein - CAS 491-67-8 - Calbiochem

196322
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
196322-10MG Plastic ampoule 10 mg
Description
OverviewA cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC50 = 120 nM) and reverse transcriptase. Protects cortical neurons from β-amyloid induced toxicity. Reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Also inhibits cellular Ca2+ uptake and mobilization, and adjuvant-induced arthritis. Reported to inhibit microsomal lipid peroxidation by forming an iron-baicalein complex. Inhibits topoisomerase II and induces cell death in hepatocellular carcinoma cell lines. Potentiates contractile responses to nerve stimulation. Inhibits protein tyrosine kinase and PMA-stimulated protein kinase C.
Catalogue Number196322
Brand Family Calbiochem®
Synonyms5,6,7-Trihydroxyflavone
References
ReferencesLeabeau, A., et al. 2001. Neuroreport 12, 2199.
Gao, D., et al. 1996. Biochem. Mol. Biol. Int. 39, 215.
Matsuzaki, Y., et al. 1996. Jpn. J. Cancer Res. 87, 170.
Huang, H.C., et al. 1994. Eur. J. Pharmacol. 268, 73.
Butenko, I.G., et al. 1993. Agents Actions 39, C49.
Abe, K., et al. 1990. Chem. Pharm. Bull. 38, 209.
Kimura, Y., et al. 1987. Biochim. Biophys. Acta 922, 278.
Sekiya, K., and Okuda, H. 1982. Biochem. Biophys. Res. Commun. 105, 1090.
Product Information
CAS number491-67-8
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₅H₁₀O₅
Chemical formulaC₁₅H₁₀O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target12-lipoxygenase
Primary Target IC<sub>50</sub>120 nM against 12-lipoxygenase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Irritant
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Baicalein - CAS 491-67-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Baicalein - CAS 491-67-8 - Calbiochem Certificates of Analysis

TitleLot Number
196322

References

Reference overview
Leabeau, A., et al. 2001. Neuroreport 12, 2199.
Gao, D., et al. 1996. Biochem. Mol. Biol. Int. 39, 215.
Matsuzaki, Y., et al. 1996. Jpn. J. Cancer Res. 87, 170.
Huang, H.C., et al. 1994. Eur. J. Pharmacol. 268, 73.
Butenko, I.G., et al. 1993. Agents Actions 39, C49.
Abe, K., et al. 1990. Chem. Pharm. Bull. 38, 209.
Kimura, Y., et al. 1987. Biochim. Biophys. Acta 922, 278.
Sekiya, K., and Okuda, H. 1982. Biochem. Biophys. Res. Commun. 105, 1090.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-August-2018 JSW
Synonyms5,6,7-Trihydroxyflavone
DescriptionA cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC50 = 120 nM) and reverse transcriptase. Reduces leukotriene biosynthesis and the release of lysosomal enzymes. Also inhibits cellular Ca2+ uptake and mobilization, and adjuvant-induces arthritis. Potentiates contractile responses to nerve stimulation. Inhibits protein tyrosine kinase and PMA-stimulated PKC.
FormYellow solid
CAS number491-67-8
Chemical formulaC₁₅H₁₀O₅
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (20 mg/ml) or Acetone
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Irritant
Merck USA index14, 942
ReferencesLeabeau, A., et al. 2001. Neuroreport 12, 2199.
Gao, D., et al. 1996. Biochem. Mol. Biol. Int. 39, 215.
Matsuzaki, Y., et al. 1996. Jpn. J. Cancer Res. 87, 170.
Huang, H.C., et al. 1994. Eur. J. Pharmacol. 268, 73.
Butenko, I.G., et al. 1993. Agents Actions 39, C49.
Abe, K., et al. 1990. Chem. Pharm. Bull. 38, 209.
Kimura, Y., et al. 1987. Biochim. Biophys. Acta 922, 278.
Sekiya, K., and Okuda, H. 1982. Biochem. Biophys. Res. Commun. 105, 1090.