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203303 Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem

203303
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₁H₁₅N₃O₂113963-68-1

Products

Catalogue NumberPackaging Qty/Pack
203303-1MG Plastic ampoule 1 mg
203303-250UG Plastic ampoule 250 μg
Description
OverviewA cell-permeable negative control compound for protein kinase C inhibition studies (IC50 >100 µM). Blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k in vivo (IC50 8 µM).
Catalogue Number203303
Brand Family Calbiochem®
Synonyms2,3-bis(1H-Indol-3-yl)-N-methylmaleimide, Ro 31-6045
References
ReferencesMarmy-Conus, N., et al. 2002. FEBS Lett. 26094 (In Press) 1-6.
Davis, P.D., et al. 1992. J. Med. Chem. 35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
Product Information
CAS number113963-68-1
ATP CompetitiveN
FormRedish orange solid
Hill FormulaC₂₁H₁₅N₃O₂
Chemical formulaC₂₁H₁₅N₃O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNegative control compound for protein kinase C inhibition
Primary Target IC<sub>50</sub>>100 µM as negative control compound for protein kinase C inhibition; 8 µM in blocking the activation of mitogen-stimulated protein kinase p70s6k/p85s6k in vivo
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem Certificates of Analysis

TitleLot Number
203303

References

Reference overview
Marmy-Conus, N., et al. 2002. FEBS Lett. 26094 (In Press) 1-6.
Davis, P.D., et al. 1992. J. Med. Chem. 35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-May-2008 RFH
Synonyms2,3-bis(1H-Indol-3-yl)-N-methylmaleimide, Ro 31-6045
DescriptionA cell-permeable negative control compound for protein kinase C inhibition studies (IC50 > 100 µM). Blocks the activation of p70s6k/p85s6k in vivo (IC50 = 8 µM).
FormRedish orange solid
CAS number113963-68-1
Chemical formulaC₂₁H₁₅N₃O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml) or Methanol (5 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesMarmy-Conus, N., et al. 2002. FEBS Lett. 26094 (In Press) 1-6.
Davis, P.D., et al. 1992. J. Med. Chem. 35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.