Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

236603 C-Reactive Protein, Human Serum, High Purity

236603
Purchase on Sigma-Aldrich

Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
236603-100UG Glass bottle 100 μg
Description
OverviewNative C-reactive protein highly purified from human serum. CRP is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca2+-dependent binding to a variety of substrates. Important in diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer. Intended for use as a calibration standard for assays of CRP, for structural and functional studies, and as an antigen for production of antisera. Calibrated by electroimmunoassay against WHO reference standard or equivalent.
M.W. 23,000 (monomer); 115,000 (pentamer).
No reaction in ODD and Laurell electroimmunoassay against polyvalent antiserum to normal human serum, antiserum to pooled effusion fluids and monospecific antiserum to human IgG.
Catalogue Number236603
Brand Family Calbiochem®
SynonymsCRP
References
ReferencesPaffen, E., et al. 2004. Arterioscler. Thromb. Vasc. Biol. 24, 975.
Product Information
CAS number9007-41-4
FormLiquid
FormulationIn 140 mM NaCl, 10 mM Tris, 2 mM CaCl₂, 0.1% NaN₃, pH 8.0.
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by SDS-PAGE
SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

C-Reactive Protein, Human Serum, High Purity SDS

Title

Safety Data Sheet (SDS) 

C-Reactive Protein, Human Serum, High Purity Certificates of Analysis

TitleLot Number
236603

References

Reference overview
Paffen, E., et al. 2004. Arterioscler. Thromb. Vasc. Biol. 24, 975.

Citations

Title
  • Paramita Baruah, et al. (2006) The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells and edits the cross-presentation of self, viral and tumor antigens. Blood 107, 151-158.
  • Elaine Paffen, Hans L. Vos and Rogier M. Bertina. (2004) C-Reactive Protein Does Not Directly Induce Tissue Factor in Human Monocytes. Arteriosclerosis, Thrombosis, and Vascular Biology 24, 975-981.
  • Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision27-September-2007 RFH
    SynonymsCRP
    DescriptionNative C-reactive protein highly purified from human serum. CRP is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca2+-dependent binding to a variety of substrates. Important in diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer. Intended for use as a calibration standard for assays of CRP, for structural and functional studies, and as an antigen for production of antisera. Calibrated by electroimmunoassay against WHO reference standard or equivalent.
    FormLiquid
    FormulationIn 140 mM NaCl, 10 mM Tris, 2 mM CaCl₂, 0.1% NaN₃, pH 8.0.
    SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
    CAS number9007-41-4
    Purity≥99% by SDS-PAGE
    Storage ≤ -70°C
    Avoid freeze/thaw
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
    Toxicity Standard Handling
    Merck USA index14, 2603
    ReferencesPaffen, E., et al. 2004. Arterioscler. Thromb. Vasc. Biol. 24, 975.
    Citation
  • Paramita Baruah, et al. (2006) The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells and edits the cross-presentation of self, viral and tumor antigens. Blood 107, 151-158.
  • Elaine Paffen, Hans L. Vos and Rogier M. Bertina. (2004) C-Reactive Protein Does Not Directly Induce Tissue Factor in Human Monocytes. Arteriosclerosis, Thrombosis, and Vascular Biology 24, 975-981.