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234415 C5a Receptor Antagonist, W-54011 - CAS 405098-33-1 - Calbiochem

234415
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₃₀H₃₆N₂O₂ • HCl405098-33-1

Products

Catalogue NumberPackaging Qty/Pack
234415-1MG Plastic ampoule 1 mg
234415-5MG Plastic ampoule 5 mg
Description
OverviewA tetrahydronaphthalenyl carboxamide compound that acts as a potent, specific and orally active C5a receptor antagonist. Shown to inhibit the binding of 125I-rhC5a to human neutrophils with a Ki of 2.2 nM, as well as C5a-induced intracellular Ca2+-mobilization, chemotaxis and reactive oxygen species (ROS) generation (IC50 = 3.1 nM, 2.7 nM and 1.6 nM, respectively) with no agonist activity up to 10 µM. Shown to prevent C5a-induced neutrophenia in gerbils (100 µg/kg i.v. or 3-30 mg/kg orally).
Catalogue Number234415
Brand Family Calbiochem®
SynonymsN-((4-Dimethylaminophenyl)methyl)-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-carboxamide, HCl
References
ReferencesSumichika, H., et al. 2002. J. Biol. Chem. 277, 49403.
Product Information
CAS number405098-33-1
ATP CompetitiveN
FormWhite solid
Hill FormulaC₃₀H₃₆N₂O₂ • HCl
Chemical formulaC₃₀H₃₆N₂O₂ • HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetC5a Receptor
Primary Target IC<sub>50</sub>3.1 nM, 2.7 nM and 1.6 nM against C5a-induced intracellular Ca2+-mobilization, chemotaxis and reactive oxygen species (ROS) generation, respectively
Primary Target K<sub>i</sub>2.2 nM against the binding of 125I-rhC5a to human neutrophils
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

C5a Receptor Antagonist, W-54011 - CAS 405098-33-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

C5a Receptor Antagonist, W-54011 - CAS 405098-33-1 - Calbiochem Certificates of Analysis

TitleLot Number
234415

References

Reference overview
Sumichika, H., et al. 2002. J. Biol. Chem. 277, 49403.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-June-2008 RFH
SynonymsN-((4-Dimethylaminophenyl)methyl)-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-carboxamide, HCl
DescriptionA potent, specific, and orally active C5a receptor antagonist. Shown to inhibit the binding of 125I-rhC5a to human neutrophils with a Ki of 2.2 nM, as well as C5a-induced intracellular Ca2+-mobilization, chemotaxis and reactive oxygen species (ROS) generation (IC50 = 3.1 nM, 2.7 nM and 1.6 nM, respectively) with no agonist activity up to 10 µM. Shown to prevent C5a-induced neutrophenia in gerbils (100 µg/kg i.v. or 3-30 mg/kg orally).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number405098-33-1
Chemical formulaC₃₀H₃₆N₂O₂ • HCl
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml) or Methanol (50 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSumichika, H., et al. 2002. J. Biol. Chem. 277, 49403.