Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

205530 CA-074 - Calbiochem

205530
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₈H₂₉N₃O₆

Products

Catalogue NumberPackaging Qty/Pack
205530-1MG Plastic ampoule 1 mg
Description
OverviewAn epoxysuccinyl peptide that acts as a potent, irreversible, and specific inhibitor of cathepsin B (IC50 = 2.24 nM for rat liver cathepsin B). Reduces ischemia-induced neuronal death. Exhibits lower membrane permeability when compared to CA-074 Me (Cat. No. 205531).
Catalogue Number205530
Brand Family Calbiochem®
SynonymsCathepsin B Inhibitor III, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline
References
ReferencesChan, V.J., et al. 1999. Biochem. J. 340, 113.
Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187.
Yamamoto, A., et al. 1997. J. Biochem. 121, 974.
Inubushi, T., et al. 1994. J. Biochem. 116, 282.
Murata, M., et al. 1991. FEBS Lett. 280, 307.
Towatari, T., et al. 1991. FEBS Lett. 280, 311.
Product Information
ATP CompetitiveN
FormColorless or white solid
Hill FormulaC₁₈H₂₉N₃O₆
Chemical formulaC₁₈H₂₉N₃O₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcathepsin B
Primary Target IC<sub>50</sub>2.24 nM for rat liver cathepsin B
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

CA-074 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

CA-074 - Calbiochem Certificates of Analysis

TitleLot Number
205530

References

Reference overview
Chan, V.J., et al. 1999. Biochem. J. 340, 113.
Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187.
Yamamoto, A., et al. 1997. J. Biochem. 121, 974.
Inubushi, T., et al. 1994. J. Biochem. 116, 282.
Murata, M., et al. 1991. FEBS Lett. 280, 307.
Towatari, T., et al. 1991. FEBS Lett. 280, 311.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-May-2008 RFH
SynonymsCathepsin B Inhibitor III, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline
DescriptionA potent, irreversible inhibitor of Cathepsin B in vivo and in vitro (IC50 = 2.24 nM for rat liver cathepsin B).
FormColorless or white solid
Chemical formulaC₁₈H₂₉N₃O₆
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesChan, V.J., et al. 1999. Biochem. J. 340, 113.
Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187.
Yamamoto, A., et al. 1997. J. Biochem. 121, 974.
Inubushi, T., et al. 1994. J. Biochem. 116, 282.
Murata, M., et al. 1991. FEBS Lett. 280, 307.
Towatari, T., et al. 1991. FEBS Lett. 280, 311.