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219677 CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem

219677
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₆H₂₂N₄O₃931706-15-9

Products

Catalogue NumberPackaging Qty/Pack
219677-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable pyrimido-pyrrolo-quinoxalinedione (PPQ) compound that targets the intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR-mediated chloride current in a reversible and voltage-independent manner. Single channel recordings of CFTR-expressing FRT cells upon forskolin (Cat. No. 344270) and IBMX (Cat. No. 410957) stimulation indicate that the nature of PPQ-102 inhibition is due to a stabilization of the channels in a closed state (7.8- vs. 0.4-fold increase of mean channel close vs. open time, respectively, with 1 µM PPQ-102). PPQ-102 at 5 µM is shown to completely prevent Sp-8-Br-cAMP- (Cat. No. 116818) induced cysts formation and reduce the size of preformed cysts in an ex vivo murine neonatal kidney organ culture.
Catalogue Number219677
Brand Family Calbiochem®
Synonyms7,9-Dimethyl-11-phenyl-6-(5-methylfuran-2-yl)-5,6-dihydro-pyrimido-[4ʹ,5ʹ-3,4]pyrrolo[1,2-a]quinoxaline-8,10-(7H,9H)-dione, Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV
References
ReferencesTradtrantip, L., et al. 2009. J. Med. Chem. 52, 6447.
Product Information
CAS number931706-15-9
FormWhite crystalline solid
Hill FormulaC₂₆H₂₂N₄O₃
Chemical formulaC₂₆H₂₂N₄O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationCFTR Inhibitor IV, PPQ-102, CAS 931706-15-9, is a cell-permeable inhibitor of CFTR-mediated chloride current in a reversible and voltage-independent manner.
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem Certificates of Analysis

TitleLot Number
219677

References

Reference overview
Tradtrantip, L., et al. 2009. J. Med. Chem. 52, 6447.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
Synonyms7,9-Dimethyl-11-phenyl-6-(5-methylfuran-2-yl)-5,6-dihydro-pyrimido-[4ʹ,5ʹ-3,4]pyrrolo[1,2-a]quinoxaline-8,10-(7H,9H)-dione, Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV
DescriptionA cell-permeable pyrimido-pyrrolo-quinoxalinedione (PPQ) compound that targets the intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR-mediated chloride current in a reversible and voltage-independent manner. Single channel recordings of CFTR-expressing FRT cells upon forskolin (Cat. No. 344270) and IBMX (Cat. No. 410957) stimulation indicate that the nature of PPQ-102 inhibition is due to a stabilization of the channels in a closed state (7.8- vs. 0.4-fold increase of mean channel close vs. open time, respectively, with 1 µM PPQ-102). PPQ-102 at 5 µM is shown to completely prevent Sp-8-Br-cAMP- (Cat. No. 116818) induced cysts formation and reduce the size of preformed cysts in an ex vivo murine neonatal kidney organ culture.
FormWhite crystalline solid
Intert gas (Yes/No) Packaged under inert gas
CAS number931706-15-9
Chemical formulaC₂₆H₂₂N₄O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTradtrantip, L., et al. 2009. J. Med. Chem. 52, 6447.