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236012 COX-2 Inhibitor II - CAS 181696-33-3 - Calbiochem

236012
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₆H₁₂F₂N₂O₃S181696-33-3

Products

Catalogue NumberPackaging Qty/Pack
236012-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable isoxazolyl-benzenesulfonamide compound that acts as a potent and highly selective inhibitor of COX-2 both in vitro (IC50 = 4 nM for hCOX-2 vs. 114 µM for hCOX-1) and in vivo. Has been used extensively in various animal models to study the role of COX-2 in wound healing process.
Catalogue Number236012
Brand Family Calbiochem®
SynonymsSC-791, 4-[(5-Difluoromethyl-3-phenyl)-4-isoxazolyl]benzenesulfonamide
References
ReferencesBlomme, E.A., et al. 2003. Br. J. Dermatol. 148, 211.
Hardy, M.M., et al. 2003. J. Pharmacol. Exp. Ther. 304, 959.
Product Information
CAS number181696-33-3
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₁₆H₁₂F₂N₂O₃S
Chemical formulaC₁₆H₁₂F₂N₂O₃S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargethCOX-2
Primary Target IC<sub>50</sub>4 nM for hCOX-2 vs. 114 µM for hCOX-1
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

COX-2 Inhibitor II - CAS 181696-33-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

COX-2 Inhibitor II - CAS 181696-33-3 - Calbiochem Certificates of Analysis

TitleLot Number
236012

References

Reference overview
Blomme, E.A., et al. 2003. Br. J. Dermatol. 148, 211.
Hardy, M.M., et al. 2003. J. Pharmacol. Exp. Ther. 304, 959.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-April-2011 RFH
SynonymsSC-791, 4-[(5-Difluoromethyl-3-phenyl)-4-isoxazolyl]benzenesulfonamide
DescriptionA cell-permeable, potent, and highly selective inhibitor of cyclooxygenase-2 (COX-2) both in vitro (IC50 = 4 nM for hCOX-2 vs. 114 µM for hCOX-1) and in vivo. Extensively used in various animal models to study the role of COX-2 in the wound healing process.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number181696-33-3
Chemical formulaC₁₆H₁₂F₂N₂O₃S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (5 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBlomme, E.A., et al. 2003. Br. J. Dermatol. 148, 211.
Hardy, M.M., et al. 2003. J. Pharmacol. Exp. Ther. 304, 959.