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239819 CXCR2 antagonist, Cpd 19 - CAS 473728-67-5 - Calbiochem

239819
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₈H₂₁N₃O₄473728-67-5

Products

Catalogue NumberPackaging Qty/Pack
239819-2MG Glass bottle 2 mg
Description
OverviewA cell-permeable, cyclobutenedione derivative that acts as a potent antagonist of chemokine receptor CXCR2 (IL8RB) (IC50 = 8 nM). Reported to inhibit CXCR2-mediated chemotaxis in a CXCR2 expressing cell line (IC50 = 145 nM). Exhibits good stability in human and rat liver microsomal preparations (> 50% remaining after 30 min at 37°C).
Catalogue Number239819
Brand Family Calbiochem®
Synonyms3-(2-(cyclopentylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide
Application Data
References
ReferencesMerritt, J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 4107.
Product Information
CAS number473728-67-5
FormOff-white solid
Hill FormulaC₁₈H₂₁N₃O₄
Chemical formulaC₁₈H₂₁N₃O₄
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

CXCR2 antagonist, Cpd 19 - CAS 473728-67-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

CXCR2 antagonist, Cpd 19 - CAS 473728-67-5 - Calbiochem Certificates of Analysis

TitleLot Number
239819

References

Reference overview
Merritt, J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 4107.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-July-2014 JSW
Synonyms3-(2-(cyclopentylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide
Application Data
DescriptionA cell-permeable, cyclobutenedione derivative that acts as a potent antagonist of chemokine receptor CXCR2 (IL8RB) (IC50 = 8 nM). Reported to inhibit CXCR2-mediated chemotaxis in a CXCR2 expressing cell line (IC50 = 145 nM). Exhibits good stability in human and rat liver microsomal preparations (> 50% remaining after 30 min at 37°C).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number473728-67-5
Chemical formulaC₁₈H₂₁N₃O₄
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml; light brown solution)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Regulatory Review
ReferencesMerritt, J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 4107.