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208923 CaMKII Inhibitor XII - Calbiochem

208923
Purchase on Sigma-Aldrich

Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
208923-5MG Glass bottle 5 mg
Description
OverviewA pyrimidinyl sulfonamide compound that acts as a potent, reversible and CaM non-competitive inhibitor of CaMKII activities (IC50 = 0.063 µM) with excellent selectivity over several kinases (IC50 = >60, 36, 11, 30 and 21 µM for CaMKIV, MLCK, p38α, Akt1 and PKC, respectively). Shown to exhibit ~25-fold greater potency towards CaMKII than the CaM-competitive inhibitor KN-93 (Cat. No. 422708).
Catalogue Number208923
Brand Family Calbiochem®
SynonymsCa2+/Calmodulin-Dependent Protein Kinase II Inhibitor XII
References
ReferencesAsano, S., et al. 2010. Bioorg. Med. Chem. Lett. 20, 6696.
Product Information
FormWhite powder
Hill FormulaC₂₉H₃₀ClN₅O₂S
Chemical formulaC₂₉H₃₀ClN₅O₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

CaMKII Inhibitor XII - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Asano, S., et al. 2010. Bioorg. Med. Chem. Lett. 20, 6696.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-August-2013 JSW
SynonymsCa2+/Calmodulin-Dependent Protein Kinase II Inhibitor XII
DescriptionA pyrimidinyl sulfonamide compound that acts as a potent, reversible and CaM non-competitive inhibitor of CaMKII activities (IC50 = 0.063 µM) with excellent selectivity over several kinases (IC50 = >60, 36, 11, 30 and 21 µM for CaMKIV, MLCK, p38α, Akt1 and PKC, respectively). Shown to exhibit ~25-fold greater potency towards CaMKII than the CaM-competitive inhibitor KN-93 (Cat. No. 422708).
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₉H₃₀ClN₅O₂S
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (100 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesAsano, S., et al. 2010. Bioorg. Med. Chem. Lett. 20, 6696.