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205548 Caffeine - CAS 58-08-2 - Calbiochem

205548
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₈H₁₀N₄O₂58-08-2

Products

Catalogue NumberPackaging Qty/Pack
205548-500GM Glass bottle 500 gm
Description
OverviewTrimethylated xanthine that acts as a potent central nervous system stimulant. At higher doses, produces tachycardia and interferes with the uptake and storage of Ca2+ by the sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by Camptothecin (Cat. No. 208925) and topotecan in HL-60 cells.
Catalogue Number205548
Brand Family Calbiochem®
Synonyms3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
References
ReferencesZhen, W., and Vaugha, A. T. 1995. Radiat. Res. 141, 170.
Howell, L. L. 1993. Cancer Res. 54, 4993.
Traganos, F., et al. 1993. Cancer Res. 53, 4613.
Zahradnik, I., and Palade, P. 1993. Pflugers Arch. 424, 129.
Product Information
CAS number58-08-2
ATP CompetitiveN
FormWhite solid
Hill FormulaC₈H₁₀N₄O₂
Chemical formulaC₈H₁₀N₄O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationCaffeine, CAS 58-08-2, is a trimethylated xanthine that acts as a potent central nervous system stimulant. At higher doses, produces tachycardia.
Biological Information
Primary TargetPotent central nervous system stimulant
Purity≥99% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSEV6475000
Safety Information
R PhraseR: 22;

Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Caffeine - CAS 58-08-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Caffeine - CAS 58-08-2 - Calbiochem Certificates of Analysis

TitleLot Number
205548

References

Reference overview
Zhen, W., and Vaugha, A. T. 1995. Radiat. Res. 141, 170.
Howell, L. L. 1993. Cancer Res. 54, 4993.
Traganos, F., et al. 1993. Cancer Res. 53, 4613.
Zahradnik, I., and Palade, P. 1993. Pflugers Arch. 424, 129.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Tools and Tips for Analyzing Apoptosis
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-March-2018 JSW
Synonyms3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
DescriptionTrimethylated xanthine that acts as a potent central nervous system stimulant. A nonselective phosphodiesterase inhibitor. At higher doses, produces tachycardia and interferes with the uptake and storage of Ca2+ by the sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by camptothecin and topotecan in HL-60 cells.
FormWhite solid
CAS number58-08-2
RTECSEV6475000
Chemical formulaC₈H₁₀N₄O₂
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityChloroform (50 mg/ml)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
Merck USA index14, 1636
ReferencesZhen, W., and Vaugha, A. T. 1995. Radiat. Res. 141, 170.
Howell, L. L. 1993. Cancer Res. 54, 4993.
Traganos, F., et al. 1993. Cancer Res. 53, 4613.
Zahradnik, I., and Palade, P. 1993. Pflugers Arch. 424, 129.