Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

05-23-2401 Calcitonin, Salmon

05-23-2401
Purchase on Sigma-Aldrich

Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
05-23-2401-25MG Plastic ampoule 25 mg
Description
OverviewSynthetic, salmon calcitonin. A 32 amino acid residue peptide that is shown to stimulate bone formation and inhibit bone resorption. Has ability to cross mucous membranes. Has no significant effect on inositol phosphate accumulation.
Catalogue Number05-23-2401
Brand Family Calbiochem®
References
ReferencesGennari, C. and Agnusdei, D. 1994. Br. J. Clin. Pract. 48, 196.
Reginster, J.Y. 1993. Osteoporos. Int. 3 (Suppl. 2), S3.
MacIntyre, I. et al. 1988. Clin. Orthop. 217, 45.
Chambers, T.J., et al. 1985. J. Pathol. 145, 297.
Product Information
CAS number47931-85-1
FormLyophilized
FormulationSold on the basis of peptide content.
Hill FormulaC₁₄₅H₂₄₀N₄₄O₄₈S₂
Chemical formulaC₁₄₅H₂₄₀N₄₄O₄₈S₂
Hygroscopic Hygroscopic
Sold on the basis of peptide contentY
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Peptide ContentY
Peptide SequenceH-Cys¹-Ser-Asn-Leu-Ser-Thr-Cys⁷-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH₂(disulfide bond: 1 → 7)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSEV8000000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Calcitonin, Salmon SDS

Title

Safety Data Sheet (SDS) 

Calcitonin, Salmon Certificates of Analysis

TitleLot Number
05-23-2401

References

Reference overview
Gennari, C. and Agnusdei, D. 1994. Br. J. Clin. Pract. 48, 196.
Reginster, J.Y. 1993. Osteoporos. Int. 3 (Suppl. 2), S3.
MacIntyre, I. et al. 1988. Clin. Orthop. 217, 45.
Chambers, T.J., et al. 1985. J. Pathol. 145, 297.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-September-2008 RFH
DescriptionSynthetic, salmon calcitonin. Calcitonin is a single-chain peptide hormone of 32 amino acid residues with a disulfide bridge between cysteines 1 and 7. It is produced in the parafollicular C cells of the thyroid gland and acts to stimulate bone formation by osteoblasts and inhibits bone resorption. Part of the effect of calcitonin appears to be mediated through increasing cAMP concentrations in osteoclasts. Has ability to cross mucus membranes. Has no significant effect on inositol phosphate accumulation.
FormLyophilized
FormulationSold on the basis of peptide content.
CAS number47931-85-1
RTECSEV8000000
Chemical formulaC₁₄₅H₂₄₀N₄₄O₄₈S₂
Peptide SequenceH-Cys¹-Ser-Asn-Leu-Ser-Thr-Cys⁷-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH₂(disulfide bond: 1 → 7)
Purity≥98% by HPLC
Solubility5% Acetic acid (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
Merck USA index14, 1643
ReferencesGennari, C. and Agnusdei, D. 1994. Br. J. Clin. Pract. 48, 196.
Reginster, J.Y. 1993. Osteoporos. Int. 3 (Suppl. 2), S3.
MacIntyre, I. et al. 1988. Clin. Orthop. 217, 45.
Chambers, T.J., et al. 1985. J. Pathol. 145, 297.