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208293 Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 - Calbiochem

208293
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₈H₂₁NO₄S

Products

Catalogue NumberPackaging Qty/Pack
208293-10MG Glass bottle 10 mg
Description
OverviewAn aminothiophene that inhibits Calcium-activated Chloride Channel (CaCC) current influx induced by multiple calcium-elevating agonists (IC50 = 10 µM) without inhibiting calcium elevation, and CaMKII and CFTR activity. Inhibits CaCC chloride response following agonist stimulation in human bronchial and intestinal epithelial cells. Also demonstrates an inhibitory effect on TMEM16A channels (IC50 = 2.1 µM). Also available as a 100 mM solution in DMSO (Cat. No. 508628).
Catalogue Number208293
Brand Family Calbiochem®
Synonyms6-tert-butyl-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid, CaCC Blocker I, ANO Blocker I, Anoctamin Blocker I, TMEM16 Blocker I
References
ReferencesFuente, R., et al. 2011, Mol Pharmacol. 73, 758.
Namkung, W., et al. 2011, J Biol Chem. 286, 2365.
Product Information
FormOff-white solid
Hill FormulaC₁₈H₂₁NO₄S
Chemical formulaC₁₈H₂₁NO₄S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 - Calbiochem Certificates of Analysis

TitleLot Number
208293

References

Reference overview
Fuente, R., et al. 2011, Mol Pharmacol. 73, 758.
Namkung, W., et al. 2011, J Biol Chem. 286, 2365.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-May-2012 JSW
Synonyms6-tert-butyl-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid, CaCC Blocker I, ANO Blocker I, Anoctamin Blocker I, TMEM16 Blocker I
DescriptionAn aminothiophene that inhibits Calcium-activated Chloride Channel (CaCC) current influx induced by multiple calcium-elevating agonists (IC50 = 10 µM) without inhibiting calcium elevation, and CaMKII and CFTR activity. Inhibits CaCC chloride response following agonist stimulation in human bronchial and intestinal epithelial cells. Also demonstrates an inhibitory effect on TMEM16A channels (IC50 = 2.1 µM).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₈H₂₁NO₄S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml; pale yellow solution)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesFuente, R., et al. 2011, Mol Pharmacol. 73, 758.
Namkung, W., et al. 2011, J Biol Chem. 286, 2365.