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208920 Calmodulin Kinase IINtide - Calbiochem

208920
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₃₆H₂₄₀N₄₄O₃₉

Products

Catalogue NumberPackaging Qty/Pack
208920-1MG Plastic ampoule 1 mg
Description
OverviewA potent and specific inhibitor of CaMK II (IC50 = 50 nM for both the total and Ca2+-independent CaMK II activity). Exhibits inhibitory activity across converged species, including rat brain, goldfish brain, and Drosophila (IC50 range 100-400 nM). Does not affect the activities of CaMK I, CaMK IV, CaMKK, PKA, or PKC. The peptide sequence corresponds to the inhibitory domain of CaMK IIN.
Catalogue Number208920
Brand Family Calbiochem®
SynonymsKRPPKLGQIGRAKRVVIEDDRIDDVLK-OH
References
ReferencesSoderling, T.R., et al. 2001. J. Biol. Chem. 276, 3719.
Chang, B.H., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 10890.
Pereda, A.E., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13272.
Product Information
ATP CompetitiveN
FormOff-white solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₃₆H₂₄₀N₄₄O₃₉
Chemical formulaC₁₃₆H₂₄₀N₄₄O₃₉
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetCam Kinase-2
Primary Target IC<sub>50</sub>50 nM for both the total and Ca2+-independent CaMK II activity
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-Lys-Arg-Pro-Pro-Lys-Leu-Gly-Gln-Ile-Gly-Arg-Ala-Lys-Arg-Val-Val-Ile-Glu-Asp-Asp-Arg-Ile-Asp-Asp-Val-Leu-Lys-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Calmodulin Kinase IINtide - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Calmodulin Kinase IINtide - Calbiochem Certificates of Analysis

TitleLot Number
208920

References

Reference overview
Soderling, T.R., et al. 2001. J. Biol. Chem. 276, 3719.
Chang, B.H., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 10890.
Pereda, A.E., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13272.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-May-2008 RFH
SynonymsKRPPKLGQIGRAKRVVIEDDRIDDVLK-OH
DescriptionA potent and specific inhibitor of calmodulin kinase II (CaM-KII) (IC50 = 50 nM for both total and Ca2+-independent activities of CaM-KII). Does not affect the activities of CaM-KI, CaM-KIV, CaM-KK, PKA, or PKC. The peptide sequence corresponds to the inhibitory domain of the inhibitory protein, CaM-KIIN. A cell-permeable version is available under Cat. No. 208921.
FormOff-white solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₃₆H₂₄₀N₄₄O₃₉
Peptide SequenceH-Lys-Arg-Pro-Pro-Lys-Leu-Gly-Gln-Ile-Gly-Arg-Ala-Lys-Arg-Val-Val-Ile-Glu-Asp-Asp-Arg-Ile-Asp-Asp-Val-Leu-Lys-OH
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Toxicity Standard Handling
ReferencesSoderling, T.R., et al. 2001. J. Biol. Chem. 276, 3719.
Chang, B.H., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 10890.
Pereda, A.E., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13272.