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208921 Calmodulin Kinase IINtide, Myristoylated - Calbiochem

208921
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₅₆H₂₇₅N₄₇O₄₃

Products

Catalogue NumberPackaging Qty/Pack
208921-1MG Plastic ampoule 1 mg
Description
OverviewThe myristoylated form of CaMK IINtide (Cat. No. 208920). The peptide has been modified at the amino terminal lysine with the addition of three glycine residues and myristoylated to improve cell-permeability.
Catalogue Number208921
Brand Family Calbiochem®
SynonymsMyr-N-GGGKRPPKLGQIGRAKRVVIEDDRIDDVLK-OH
References
ReferencesSodering, T.R., et al. 2001. J. Biol. Chem. 276, 3719.
Chang, B.H., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 10890.
Pereda, A.E., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13272.
Product Information
ATP CompetitiveN
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₂₅₆H₂₇₅N₄₇O₄₃
Chemical formulaC₂₅₆H₂₇₅N₄₇O₄₃
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetCalmodulin-Dependent Protein Kinase (CaM Kinase)-2
Primary Target IC<sub>50</sub>50 nM against cam Kinase-2
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceMyr-N-Gly-Gly-Gly-Lys-Arg-Pro-Pro-Lys-Leu-Gly-Gln-Ile-Gly-Arg-Ala-Lys-Arg-Val-Val-Ile-Glu-Asp-Asp-Arg-Ile-Asp-Asp-Val-Leu-Lys-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at-20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Calmodulin Kinase IINtide, Myristoylated - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Calmodulin Kinase IINtide, Myristoylated - Calbiochem Certificates of Analysis

TitleLot Number
208921

References

Reference overview
Sodering, T.R., et al. 2001. J. Biol. Chem. 276, 3719.
Chang, B.H., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 10890.
Pereda, A.E., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13272.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-May-2008 RFH
SynonymsMyr-N-GGGKRPPKLGQIGRAKRVVIEDDRIDDVLK-OH
DescriptionThe myristoylated form of CaMK IINtide (Cat. No. 208920), a potent, specific inhibitor of Ca2+/Calmodulin kinase II (CaMK II) (IC50 = 50 nM for total and Ca2+-independent CaMK II activity). The peptide sequence corresponds to the inhibitory domain of the CaMK II inhibitory protein, CaMK IIN. Exhibits inhibitory activity across converged species, including rat brain, goldfish brain, and Drosophila (IC50 = 100-400 nM). Shown to completely inhibit the phosphorylation of GluR1 fusion protein at a concentration of 1 µM. Does not inhibit CaMK I, CaMK IV, CaMKK, PKA, or PKC. The peptide has been modified at the amino terminal lysine with the addition of three glycine residues and myristoylated to improve cell-permeability.
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₅₆H₂₇₅N₄₇O₄₃
Peptide SequenceMyr-N-Gly-Gly-Gly-Lys-Arg-Pro-Pro-Lys-Leu-Gly-Gln-Ile-Gly-Arg-Ala-Lys-Arg-Val-Val-Ile-Glu-Asp-Asp-Arg-Ile-Asp-Asp-Val-Leu-Lys-OH
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at-20°C.
Toxicity Standard Handling
ReferencesSodering, T.R., et al. 2001. J. Biol. Chem. 276, 3719.
Chang, B.H., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 10890.
Pereda, A.E., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13272.