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218710 Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem

218710
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₉H₄Br₄O₂934358-00-6

Products

Catalogue NumberPackaging Qty/Pack
218710-5MG Plastic Bag(s) 5 mg
Description
OverviewA cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC50 = 7.7 µM). Also available as a 25 mM solution in DMSO (Cat. No. 218861).
Catalogue Number218710
Brand Family Calbiochem®
Synonyms(E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid, CKII Inhibitor, TBCA
References
ReferencesPagano, M.A., et al. 2006. Chembiochem 8, 129
Product Information
CAS number934358-00-6
ATP CompetitiveY
FormOff-white solid
Hill FormulaC₉H₄Br₄O₂
Chemical formulaC₉H₄Br₄O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationCasein Kinase II Inhibitor III, TBCA, CAS 934358-00-6, is a cell-permeable, potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM).
Biological Information
Primary TargetCasein Kinase II
Primary Target IC<sub>50</sub>110 nM
Primary Target K<sub>i</sub>77 nM against Casein Kinase II
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem Certificates of Analysis

TitleLot Number
218710

References

Reference overview
Pagano, M.A., et al. 2006. Chembiochem 8, 129
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-April-2008 RFH
Synonyms(E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid, CKII Inhibitor, TBCA
DescriptionA cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC50 = 7.7 µM).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number934358-00-6
Chemical formulaC₉H₄Br₄O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml). Use only fresh DMSO.
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesPagano, M.A., et al. 2006. Chembiochem 8, 129