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218714 Casein Kinase II Inhibitor IX, IQA - CAS 391670-48-7 - Calbiochem

218714
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₇H₁₂N₂O₃391670-48-7

Products

Catalogue NumberPackaging Qty/Pack
218714-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable indoloquinazolinone compound that acts as a potent, selective, reversible CK2 inhibitor (IC50 = 390 nM with 100 µM ATP) in an ATP- and GTP-competitive manner (Ki = 0.17 and 0.21 µM, respectively). IQA exhibits much reduced activity against PI 3-Kα/β/γ (No inhibition at 20 µM) and 48 commonly studied protein kinases (IC50 ≥10 µM with 100 µM ATP) and is more selective than TBB (Cat. Nos. 218697 and 218708) with respect to DYRK1a (IC50 = 8 and <1 µM, respectively, with 100 µM ATP).
Catalogue Number218714
Brand Family Calbiochem®
Synonyms5-Oxo-5,6-dihydroindolo[1,2-a]quinazoline-7-acetic acid
References
ReferencesPiazza, F.A., et al. 2006. Blood 108, 1698.
Di Maira, G., et al. 2005. Cell Death Differ. 12, 668.
Sarno, S., et al. 2003. Biochem. J. 374, 639.
Vangrevelinghe, E., et al. 2003. J. Med. Chem. 46, 2656.
Product Information
CAS number391670-48-7
FormLight yellow solid
Hill FormulaC₁₇H₁₂N₂O₃
Chemical formulaC₁₇H₁₂N₂O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25

Do not breathe dust.
Avoid contact with skin and eyes.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Casein Kinase II Inhibitor IX, IQA - CAS 391670-48-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Casein Kinase II Inhibitor IX, IQA - CAS 391670-48-7 - Calbiochem Certificates of Analysis

TitleLot Number
218714

References

Reference overview
Piazza, F.A., et al. 2006. Blood 108, 1698.
Di Maira, G., et al. 2005. Cell Death Differ. 12, 668.
Sarno, S., et al. 2003. Biochem. J. 374, 639.
Vangrevelinghe, E., et al. 2003. J. Med. Chem. 46, 2656.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-August-2017 JSW
Synonyms5-Oxo-5,6-dihydroindolo[1,2-a]quinazoline-7-acetic acid
DescriptionA cell-permeable indoloquinazolinone compound that acts as a potent, selective, and reversible CK2 inhibitor (IC50 = 390 nM with 100 µM ATP) in an ATP- and GTP-competitive manner (Ki = 0.17 and 0.21 µM, respectively). IQA exhibits much reduced activity against PI 3-Kα/β/γ (No inhibition at 20 µM) and 48 commonly studied protein kinases (IC50 ≥10 µM with 100 µM ATP) and is more selective than TBB (Cat. Nos. 218697 and 218708) with respect to DYRK1a (IC50 = 8 and <1 µM, respectively, with 100 µM ATP).
FormLight yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number391670-48-7
Chemical formulaC₁₇H₁₂N₂O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesPiazza, F.A., et al. 2006. Blood 108, 1698.
Di Maira, G., et al. 2005. Cell Death Differ. 12, 668.
Sarno, S., et al. 2003. Biochem. J. 374, 639.
Vangrevelinghe, E., et al. 2003. J. Med. Chem. 46, 2656.